Rofecoxib is a potent and highly selective cyclooxygenase-2 inhibitor used for the treatment of osteoarthritis and pain. Following administration of [4-(14)C]rofecoxib to intact rats, the plasma C(max) (at approximately 1 h) was followed by a secondary C(max) (at approximately 10 h), which was not observed in bile duct-cannulated rats. Following administration of [4-(14)C]5-hydroxyrofecoxib to ...

A sugar acid, 2-B4O, has been found to increase from 3.5 to 13 microM in rat serum at 36 h after food deprivation. Injections of 2-B4O (2.5 microM) into the rat III cerebral ventricle (III ICV) suppress food intake and single neuronal activity in the lateral hypothalamic area (LHA). 2-B4O is effective even in 72 h food-deprived rats. 2-B4O hyperpolarizes glucose-sensitive neurons in the LHA via...

The development of catalytic enantioselective transformations has been the focus of many research groups over the past half century and is of paramount importance to the pharmaceutical and agrochemical industries. Since the award of the Nobel Prize in 2001, the field of enantioselective transition metal catalysis has soared to new heights, with the development of more efficient catalysts and ne...

(Molecular Plant 11(10):1312-1314; October 2018; https://doi.org/10.1016/j.molp.2018.06.008) The amounts of CL and 3-H-CL shown in the original Figure 1D Supplementary 13 are inaccurate, due to an erroneous preparation mixing up samples. In addition, there is error designation spectra two peaks 1A, which spectrum designated as I should belong peak II, vice versa. We have repeated related experi...

Kitagawa, T., Sakamoto, Y., Furumi, K., and Ogura, H. 1989. Novel enzyme immunoassays for specific detection of Fusarium oxysporum f. sp. cucumerinum and for general detection of various Fusarium species. Phytopathology 79:162-165. Competitive types of two novel enzyme-linked immunosorbent assays including nine other strains of Fusarium, showed little cross-reactivity. (ELISA) for Fusarium spec...

The structural characterization of the ouabain-like sodium pump inhibitor in mammals (so-called `endogenous ouabain') has long been hindered by the paucity of the sample material. While many microscale structural analyses, including LC/MS and sugar analysis, could not differentiate `endogenous ouabain' from ouabain, our past nanogram-scale `pentanaphthoylation' followed by HPLC and circular dic...

•Copper-catalyzed carbonylative four-component coupling of olefins•Boration and carbonylation in one pot•Two molecules CO regarded as –CH2CO– source•Isotope-labeling 13CO experiment is provided Carbon monoxide (CO) can be produced from any type carbon-containing sources, including wasters. The incorporation into organic scaffolds a central pillar synthesis. Various value-added bulky fine chemic...