1,1-Bis(3'-indolyl)-1-(p-t-butylphenyl)methane (DIM-C-pPhtBu) is a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, and treatment of SKOV3 ovarian cancer cells with this compound (5 micromol/L) inhibits cell proliferation, whereas up to 15 micromol/L rosiglitazone had no effect on cell growth. DIM-C-pPhtBu also inhibits G0-G1 to S phase cell cycle progression and this is li...

Magic blue (MB+˙ SbCl6− salt), i.e. tris-4-bromophenylamminium cation radical, is a routinely employed one-electron oxidant that slowly decomposes in the solid state upon storage to form so called ‘blues brothers’, which often complicate the quantitative analyses of the oxidation processes. Herein, we disclose the identity of the main ‘blues brother’ as the cation radical and dication of tetrak...

Transient receptor potential (TRP) channels couple various environmental factors to changes in membrane potential, calcium influx, and cell signaling. They also integrate multiple stimuli through their typically polymodal activation. Thus, although the TRPM8 channel has been extensively investigated as the major neuronal cold sensor, it is also regulated by various chemicals, as well as by seve...

BACKGROUND Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERSs). Because of chemical similarities, immunological cross-reactivity may occur. OBJECTIVES To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERSs (FP-0...

We have synthesized Deltalac-acetogenins that are new acetogenin mimics possessing two n-alkyl tails without an alpha,beta-unsaturated gamma-lactone ring and suggested that their inhibition mechanism may be different from that of common acetogenins [Hamada et al. (2004) Biochemistry 43, 3651-3658]. To elucidate the inhibition mechanism of Deltalac-acetogenins in more detail, we carried out wide...

Chalcones are well-known natural dyes, 18 different derivatives selected from the rational molecular design (i.e. through orbital calculations) were synthesized. If used in conjunction with an amine ethyl l, 4-(dimethylamino) benzoate, EDB) and iodonium salt (bis(4-tert-butylphenyl) hexafluorophosphate, Iod) as photoinitiating systems (PISs), these dyes can initiate both free radical polymeriza...

In the presence of Na(+) ions, two N(2)-modified guanosine derivatives, N(2)-(4-n-butylphenyl)-2',3',5'-O-triacetylguanosine (G1) and N(2)-(4-pyrenylphenyl)-2',3',5'-O-triacetylguanosine (G2), are found to self-associate into discrete octamers that contain two G-quartets and a central ion. In each octamer, all eight guanosine molecules are in a syn conformation and the two G-quartets are stacke...

Alveolar epithelial cell (AEC) injury and repair are important in the pathogenesis of oxidant-induced lung damage. Keratinocyte growth factor (KGF) prevents lung damage and mortality in animals exposed to various forms of oxidant stress, but the protective mechanisms are not yet established. Because DNA strand break (DNA-SB) formation is one of the earliest cellular changes that occurs after ce...

The physical properties and phase transitions of thermotropic liquid crystals are highly sensitive to small changes in chemical structure. However, these changes are challenging to model, as both the phase diagram and mesophase properties obtained from fully atomistic simulations are strongly dependent on the force field model employed, and the current generation of chemical force fields has no...

A number of new compounds of two series have been shown by miscibility studies and optical microscopy to exhibit the hitherto rare smectic F phase. An example of each series has been chosen for detailed X-ray structural investigation : terephthalylidenebis-4-n-pentylaniline (TBPA) and 4-(2'-methyl butylphenyl 4'-n-octyloxybiphenyl-4-carboxylate) (80SF). The structure of the SF phase has been de...