Anticonvulsant activity of 7-phenyl-5H-thiazolo[5,4-e][1,2,3,4]tetrazolo[5,1-c]pyrrolo[1,2-a][1,4]diazepine (5) and 7-phenyl-5H-thiazolo[5,4-e][1,3,4]triazolo[5,1-c]pyrrolo[1,2-a][1,4]diazepines (6a-d) was measured against pentylenetetrazole (PTZ)-induced seizures in mice. Intraperitoneal injections of different doses (12.5, 25 and 50 mg/kg, i.p.) of test compounds decreased PTZ-induced seizure...

Regular Gabor frames for L2(Rd) are obtained by applying time-frequency shifts from a lattice in Λ Rd× R̂d to some decent so-called Gabor atom g, which typically is something like a summability kernel in classical analysis, or a Schwartz function, or more generally some g∈ S0(R). There is always a canonical dual frame, generated by the dual Gabor atom g̃. The paper promotes a numerical approach f...

Os benzodiazepínicos (BZD’s) são drogas psicoativas que atuam como moduladores alostéricos (agonistas) do receptor de ácido γ-aminobutírico tipo A (GABAA), Sistema Nervoso Central, na prática clínica, esses medicamentos muitos utilizados e prescritos no tratamento da ansiedade, insônia depressão. Devido suas várias ações farmacológicas, o uso prolongado, torna entre os cincos fármacos mais vend...

The applicability of micellar electrokinetic capillary chromatography (MEKC) for the separation of benzodiazepine (BZD) derivates with different structural characteristics has been studied. Efforts were first focused on the optimization of the analytical conditions, on the effects of buffer concentration, surfactant concentration and buffer pH on the separation. To manipulate selectivity of the...

BACKGROUND The latest French good practice recommendations (GPRs) for the screening, prevention, and treatment of alcohol misuse were recently published in partnership with the European Federation of Addiction Societies (EUFAS). This article aims to synthesize the GPRs focused on the pharmacotherapy of alcohol dependence. METHODS A four-member European steering committee defined the questions...

BACKGROUND Dexmedetomidine (DEX) is a centrally acting alpha-2-adrenoceptor agonist that has potential in the management of alcohol withdrawal syndrome (AWS) owing to its ability to produce arousable sedation and to inhibit the adrenergic system without respiratory depression. The objective of this randomized controlled study was to evaluate whether addition of DEX to benzodiazepine (BZD) thera...

this paper deals with the assessment of the depth of the modern anesthesia. a new classification is proposed and a test is designed for monitoring the movement of the hand during complete relaxation.

Eszopiclone is the S-isomer of racemic zopiclone, a cyclopyrrolone with sedative-hypnotic activity that has been available in Europe, Canada, and Latin America since 1987. Eszopiclone acts by binding to the GABA(A) receptor. In contrast to the benzodiazepine (BZD) hypnotics, eszopiclone has more selectivity for certain subunits of the GABA(A) receptor. Oral eszopiclone is rapidly absorbed and e...

Introduction While the role of benzodiazepines (BZDs) has been well established for anxiety and related disorders, there are significant concerns about BZD dependence, withdrawal, tolerance. There is a lot ambiguity regarding potential long-term effects BZDs on mental health. However, risk developing subsequent other substance use disorders in question. Objectives In this electronic medical rec...

Several agents are known to improve sleep induction and/or maintenance in patients with insomnia disorder. These include the benzodiazepine (BZD) and non-BZD receptor allosteric modulators, the melatonin receptor agonist ramelteon, low-dose doxepin, and suvorexant. One of the drawbacks of the BZDs is their known reduction in both N3 sleep [also known as slow wave sleep or delta sleep and charac...