BACKGROUND The level of high-density lipoprotein cholesterol (HDL-C) is an important risk indicator and used in risk factor counting and quantitative risk assessment; however, the effect of HDL-C in young male patients with acute myocardial infarction (AMI) is unclear. The aim of this study was to investigate the effect of HDL-C in young male patients. METHODS We recruited 267 consecutive you...

background: we aimed to analyze the association between lipid variables and the extent and severity of coronary artery disease (cad) in non-diabetic turkish cypriots. methods: overall, 412 patients (mean (sd) age: 58.8 (10.5) yr, 50.1% male) who underwent diagnostic coronary angiography were included in this single-center, cross-sectional study. the friesinger index (fi) was used to assess the ...

BACKGROUND The association between high-density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD) events is not well described in individuals with very high levels of HDL-C (>80 mg/dL). METHODS AND RESULTS Using pooled data from 6 community-based cohorts we examined CHD and total mortality risks across a broad range of HDL-C, including values in excess of 80 mg/dL. We used Cox ...

Abstaract: Objective: To investigate whether the risk profile for coronary heart disease (CHD) is more favorable in individuals with high tetraplegia (neurological lesion above C4) than in healthy controls. (Because inactivity has a negative effect on the lipid profile.) Design: Case-control study. Setting: This research was performed in the rehabilitation hospital for the spinal cord injured p...

OBJECTIVE Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans. METHODS AND RESULTS We summarized the 27 QTL and candidate genes associated wit...

High-density lipoprotein (HDL) is highly heterogeneous in its size and composition. Till now, the link of HDL subfractions to coronary risk is less clear. We aimed to investigate the associations of HDL subfractions with traditional risk factors (RFs), coronary severity, and outcomes in a cohort of nontreated patients with stable coronary artery disease (CAD). We prospectively enrolled 591 elig...

The objective of this study was to investigate serum lipoprotein levels in order to assess cardiovascular disease (CVD) risk factors between fish-consuming populations and non-fish-consuming populations, as it has been speculated that fish intake reduces CVD risk. A representative sample of one thousand subjects (529 men and 471 women) were selected, with ages ranging from 20 to 70 years, from ...

Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study. Plasma HDL-c, HDL(2)-c, HDL(3)-c, and apolipoprotein (apo)A1 levels were measured, and 13 CETP single nucleotide polymorphisms (SNPs) were genotyped in 265 blacks and 486 ...

Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL(2) and HDL(3). It also might increase the number of small, dense, low-density lipoprotein cholesterol (LDL-C) particles in hypogonadal men. The decrease in HDL-C and in LDL-C size is potentially mediated by hepatic lipase activity, which hydrolyzes lipoprotein phospholipid...

BACKGROUND AND OBJECTIVES The clinical significance of statin-induced high-density lipoprotein cholesterol (HDL-C) changes is not well known. We investigated whether rosuvastatin-induced HDL-C changes can influence the anti-oxidative action of high-density lipoprotein particle. SUBJECTS AND METHODS A total of 240 patients with stable ischemic heart disease were studied. Anti-oxidative propert...