Abstract It has become increasingly evident that even though B cells respond to both soluble and membrane-presented antigens in vitro, the primary mode of antigen recognition vivo appears be on surfaces antigen-presenting cells. To determine how sense an is membrane associated, we investigated role Piezo1 mechanosensing cation channel human B-cell activation. We discovered flux calcium when sim...

PIEZO1 is a mechanosensitive non-selective cation channel, present in many cell types including Red Blood Cells (RBCs). Together with the Gárdos forms RBCs tandem that participates rapid adjustment of volume. The pharmacology allowing functional studies roles has only recently been developed, Yoda1 as widely used agonist. In 2018, analogues were step towards an improved understanding and functi...

Determining antinociceptive interaction between Phα1β toxin (a voltage gated calcium channel blocker) and SB366791 (selective TRPV1 antagonist) may have both clinical and mechanistic implications for the pain management. This data in brief article is associated to the research paper "Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mi...

The present work studied the effect of calcium channel blocker (nimodipine) on epileptic seizures elicited by electrical stimulation of somatosensory cortex in young rats exposed to hypoxia. Rats were exposed to different patterns of short-term hypoxia (hypobaric or normobaric) and reactions of cortical neurones were registered. In the youngest animals (12-day-old), the effect was minimal, in o...

Various factors may be responsible for blood pressure alterations during perioperative care. When these physiologic alterations require treatment, several therapeutic options are available. Clevidipine is an ultrashort-acting, intravenous L-type calcium channel antagonist of the dihydropyridine class. Anecdotal experience has demonstrated its efficacy in various clinical scenarios in the pediat...

Clevidipine is a short-acting, intravenous calcium channel antagonist of the dihydropyridine class. Rapid metabolism by blood and tissue esterases results in a half-life of 1-3 minutes. We present anecdotal experience with the use of clevidipine to provide perioperative BP control in a 2-year-old child with aortic coarctation. Options for BP control in pediatric patients are discussed and previ...

Short-term treatment of the endothelium with dihydropyridine calcium antagonists resulted in an increased release in NO that is not due to a modulation of L-type calcium channels, because macrovascular endothelial cells do not express this channel. We investigated whether long-term (48 hours) treatment of porcine endothelial cell cultures with the dihydropyridine calcium antagonist nifedipine r...

High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) and a high density of PACAP binding sites have been detected in the developing rat cerebellum. In particular, PACAP receptors are actively expressed in immature granule cells, where they activate both adenylyl cyclase and phospholipase C. The aim of the present study was to investigate the ability of PACAP to indu...

debaryomyces hansenizopf isolated from the fructoplane of apples were found to be effective as biocontrol agent against rot of papaya caused by ulocladium. chartarum(pr.) simm. the ability of d. hansenii to prevent infection of u. chartarum was lost when the antagonist cells were killed by autoclaving. cell free culture filtrates of antagonist were unable to prevent disease incidence. efficacy ...