OBJECTIVE Canavan's disease is a lethal illness caused by a single gene mutation that is inherited as an autosomal recessive pattern. It has many different clinical features especially in the non-Ashkenazi Jewish population. MATERIAL & METHODS 45 patients were referred to the Pediatric Neurology Department of Mofid Children's Hospital in Tehran-Iran from 2010-2014 with a chief complaint of ne...

Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal N-methyl-D-aspartate (NMDA) receptors, and also act on group II metabotropic glutamate receptors. Oligodendrocytes and their precursors have r...

www.chestpubs.org with once daily tiotropium compared with twice daily salmeterol in patients with COPD . Thorax . 2003 ; 58 ( 5 ): 399 404 . 12 . Brusasco V , Hodder R , Miravitlles M , Korducki L , Towse L , Kesten S . Health outcomes following treatment for 6 months with once daily tiotropium compared with twice daily salmeterol in patients with COPD . Thorax . 2006 ; 61 ( 1 ): 91 . 13 . Cal...

The present study was carried out to explore the effects of oolong and green teas on improving the memory deficits and brain pathological changes in senescence accelerated-prone mice P8 (SAMP8). Six-month-old mice were supplied with oolong tea, green tea or water as the sole drinking fluid for 16 wk. The memory ability of mice was evaluated by passive and active avoidance tests, while the exten...

OBJECTIVE To describe the distribution of elastic fibres in the developing male urethra and to provide stereological data of the concentration of elastic fibres in the human urethra. MATERIALS AND METHODS Urethras were obtained from 10 fresh normal human fetuses at 15-36 weeks of gestation. A place-matched spongy urethra of a 27-year-old normal adult man was also analysed. Samples were fixed ...

Canavan's disease (CD) is a fatal autosomal recessive pediatric leukodystrophy in which patients show severe neurodegeneration and typically die by the age of 10, though life expectancy in patients can be highly variable. Currently, there is no effective treatment for CD; however, gene therapy seems to be a feasible approach to combat the disease. Being a monogenic defect, the disease provides ...

Received: November 22, 2013 Accepted: December 26, 2013 Published: January 03, 2014 neurons, astrocytes and oligodendrocytes is vital for normal brain function [1]. As such it has been described as the brain’s “operating system” [2]. NAA is synthesized by neurons from acetyl co-enzyme A (AcCoA) with the acetyl group derived from on-going oxidation of glucose (Glc), and from L-aspartate (Asp). N...

1. American Diabetes Association. Diabetes Care. 2014;37(Suppl 1):S14-S80. 2. Department of Health and Children. Changing Cardiovascular Health: National Cardiovascular Health Policy, 2010-2019. Dublin, Ireland: Department of Health and Children; 2010. http://www.dohc.ie/publications/pdf/changing_cardiovascular_ health.pdf. Accessed 3 Oct 2014. 3. Canavan R. Presented at: National Association o...

with COPD: a prospective cohort study. Chest 2011; 140: 331–342. 4 Watz H, Pitta F, Rochester CL, et al. An official European Respiratory Society statement on physical activity in COPD. Eur Respir J 2014; 44: 1521–1537. 5 Garfield BE, Canavan JL, Smith CJ, et al. Stanford Seven-Day Physical Activity Recall questionnaire in COPD. Eur Respir J 2012; 40: 356–362. 6 Williams K, Frei A, Vetsch A, et...

Background: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window opportunity following diagnosis. T-cells are early drivers synovial inflammation RA, therefore, identification pathogenic T-cell subsets at the tissue pre-RA, arthralgia subjects, would greatly improve our understanding disease pathogenesis. Comparative analysis healthy control, subject and...