Populations of cells have unique characteristics and gene markers representative of each cell type, and these features are useful for identifying cell characteristics. For example, the gene expression profile of cells differs at each stage of development and differentiation. This review focuses on gene expression in stem and cancer cells to investigate the possibility of identifying cancer stem...

Colorectal Cancer (CRC) is the second most common cancer in women and third men. There strong evidence for role of Stem Cells (CSCs) progression. The identification understanding CSCs genes such as LGR5 involved induction development crucial prognosis CRC. a membrane protein several molecular signaling pathways, Wnt NOTCH pathways. It has been shown that gene was overexpressed CRC associated wi...

The term ''oxidative stress" refers to a cell's state characterized by excessive production of reactive oxygen species (ROS) and oxidative stress is one of the most important regulatory mechanisms for stem, cancer, and cancer stem cells. The concept of cancer stem cells arose from observations of similarities between the self-renewal mechanism of stem cells and that of cancer stem cells, but co...

conclusions our results suggested that cb-nk cells progenitors could proliferate and differentiate on feeder layer of amnion membrane mscs in combination with specific cytokines to produce nk cells for immunotherapy. results combination of cytokines and msc layer yielded significant fold expansion in comparison with cytokines without feeder conditions (day 7: 5.2 ± 1.12 and 2 ± 0.78, respective...

evidence acquisition the fifty two significant articles discussing the stem cell in chronic myeloid leukemia from 1996 to 2012 were selected according to the authors’ experience. results studies have shown that primitive cml cells are less responsive to tyrosine kinase inhibitors (tkis) and are a reservoir for the relapse of multi drug resistant (mdr). conclusions following that, minimal residu...

Since the cancer stem cell concept has been widely accepted, several strategies have been proposed to attack cancer stem cells (CSC). Accordingly, stem cell markers are now preferred therapeutic targets. However, the problem of tumor specificity has not disappeared but shifted to another question: how can cancer stem cells be distinguished from normal stem cells, or more specifically, how do CS...

Cancer has been proposed as a result of abnormal control of growth and development of stem cells for more than century. This is the "cancer stem cell hypothesis". Both cancer and stem cells share many common especial properties. They are immortal and have good differentiation potential. In addition, organogenesis and carcinogenesis are very similar processes. Recently, more evidence and convinc...

BACKGROUND Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in gliomas that are functionally defined by their capacity for extensive self-renewal and formation of secondary tumors that phenocopy the original tumors. As the c-Myc oncoprotein...

T here are several sources of tumor heterogeneity which include clonal evolution, heterogeneity in the microenvironment, and the hierarchical organization of certain cancers whereby highly tumorigenic cancer stem cells differentiate into less tumorigenic progeny (Meacham & Morrison, 2013). Employing genetic fatemapping and limited dilution transplantation analyses, two studies independently dis...