− Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by abnormalities in T cell immunoregulation and hyperreactivity of B cells, leading to autoantibody production and multiorgan injuries. We investigated the effect of baicalin on aberrant immunoregulation in pristane-induced lupus mice. Mice received i.p. a single injection of 0.5 ml of pristane or P...

BACKGROUND Lupus anticoagulants prolong clotting times in phospholipid-dependent coagulation tests. Lupus Ratio assays are integrated tests for lupus anticoagulants that may be based on APTT, RVVT or dPT clotting times. If a patient is being treated with unfractionated heparin, however, the heparin prolong clotting times and the diagnosis of lupus anticoagulant is invalidated. Commercial assays...

a rare case of tuberculosis of the glans penis is described in a 60 year old lranian individual

nephritis remains an important problem in patients with systemic lupus erythematosus (sle). we conducted retrospective study to evaluate the efficiency of intravenous pulse cyclophosphamide in lupus nephritis: from 1983 to 1993, we reviewed 133 patients with biopsy proven lupus nephritis, 47 of them excluded because of short period of follow-up or defective laboratory data. eighty six patients ...

Lupus is a complex heterogeneous disease characterised by autoantibody production and immune complex deposition followed by damage to target tissues. Animal models of human diseases are an invaluable tool for defining pathogenic mechanisms and testing of novel therapeutic agents. There are perhaps more applicable murine models of lupus than any other human disease. There are spontaneous models ...

Though pleuritis and pleural effusion are common in lupus patients they are distinctly rare as the initial manifestation of lupus. Diagnosis of lupus pleuritis is also a difficult task and often costly and lengthy immunological panels are employed to diagnose it. We report one case of systemic lupus erythematosus (SLE) presenting with lupus pleuritis as the first manifestation. We propose that ...

Both human and nonhuman primates use imperative pointing to request a desired object from another individual. Gaze alternation often accompanies such pointing gestures, and in species that have no hands this can in itself function as imperative pointing. Dogs have exceptional skills in communicating with humans. The early development of these skills is suggested to have been facilitated by dome...

this paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (prca) was the first manifestation. there was seven years interval between prca onset and diagnosis of lupus. thymectomy due to thymoma had been carried out six years before but anaemia sustained. hypothyroidism and hypoparathyroidism were other associated diseases. severe anaemia and the need f...