BACKGROUND Despite a substantial progress in diagnosis and therapy, acute myocardial infarction (MI) is a major cause of mortality in the general population. A novel insight into the pathophysiology of myocardial infarction obtained by studying gene expression should help to discover novel biomarkers of MI and to suggest novel strategies of therapy. The aim of our study was to establish gene ex...

BACKGROUND Levels of tumor necrosis factor-alpha (TNF-alpha) increase with acute ischemia. However, whether elevations of TNF-alpha in the stable phase after myocardial ischemia (MI) are associated with increased risk of recurrent coronary events is unknown. METHODS AND RESULTS A nested case-control design was used to compare TNF-alpha levels obtained an average of 8.9 months after initial MI...

Activation of the basal ganglia has been shown during the preparation and execution of movement. However, the extent to which the activation during movement is related to efferent processes or feedback-related motor control remains unclear. We used motor imagery (MI), which eliminates peripheral feedback, to further investigate the role of the subthalamic area in the feedforward organization of...

BACKGROUND Patients with myocardial infarction (MI) and concomitant chronic obstructive pulmonary disease (COPD) constitute a high-risk group with increased mortality. β-Blocker therapy has been shown to reduce mortality, prevent arrhythmias, and delay heart failure development after an MI in broad populations. However, the effect of β-blockers in COPD patients is less well established and they...

OBJECTIVE We carried out a secondary analysis in high-risk patients with a previous myocardial infarction (MI) and diabetes in the Alpha Omega Trial. We tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA) will reduce the incidence of ventricular arrhythmias and fatal MI. RES...

Biochemical purifications from mammalian cells and Xenopus oocytes revealed that vertebrate Mi-2 proteins reside in multisubunit NuRD (Nucleosome Remodeling and Deacetylase) complexes. Since all NuRD subunits are highly conserved in the genomes of C. elegans and Drosophila, it was suggested that NuRD complexes also exist in invertebrates. Recently, a novel dMec complex, composed of dMi-2 and dM...

this study was conducted to determine whether precordial st segment depression in admission electrocardiogram (ecg) in patients with acute phase inferior myocardial infarction (mi) eligible for thrombolytic therapy and subsequent angiographic evaluation, influences the incidence of left anterior descending artery (lad) disease. 31 consecutively admitted patients were entered in our study. 20 pa...

The purpose of this study is to investigate the impact oxygen therapy on cardiovascular outcomes in relation sex patients with confirmed myocardial infarction (MI). DETermination role Oxygen suspected Acute Myocardial Infarction trial randomized 6,629 at 6 L/min for 6-12 hours or ambient air. In present subgroup analysis including 5,010 (1,388 women and 3,622 men) MI, we report effect supplemen...