Hub location problems are strategic network planning problems. They formalise the challenge of mutually exchanging shipments between a large set of depots. The aim is to choose a set of hubs (out of a given set of possible hubs) and connect every depot to a hub so that the total transport costs for exchanging shipments between the depots are minimised. In classical hub location problems, the un...

Schizophrenia is a heterogeneous psychiatric disorder of unknown cause or characteristic pathology. Clinical neuroscientists increasingly postulate that schizophrenia is a disorder of brain network organization. In this article we discuss the conceptual framework of this dysconnection hypothesis, describe the predominant methodological paradigm for testing this hypothesis, and review recent evi...

The Tree-of-Hubs Location Problem is studied. This problem, which combines several aspects of some location, network design and routing problems, is inspired by those transportation systems in which (i) several locations send and receive a product, and (ii) the performance can be improved by using transshipment points (hubs) where the product is collected and distributed. We want to locate a fi...

Recently, bicycles are used as exercising machines and traffic vehicles. Planetary gear trains can be used as the transmission systems with multi-speed for bicycles. The purpose of this work is to propose a design methodology for the design of automatic three-speed gear hubs with planetary gear trains for bicycles. First, applying the check list method (combining and extending methods), the des...

ARCNET is regarded as one of the most flexible industrial networking technologies to wire due to the many cabling options available to the user. ARCNET can be configured as a star network using hubs or a bus without hubs. Cabling can be coaxial, twisted-pair or fiber optics. With the proper selection of hubs, repeaters and links, cabling and topology can be mixed to a distance of four miles. No...

In the fast-developing field of expression quantitative traits loci (eQTL) studies, much interest has been concentrated on detecting genomic regions containing transcriptional regulators that influence multiple expression phenotypes (trans-hubs). In this paper, we develop statistical methods for eQTL mapping and propose a new procedure for investigating candidate trans-hubs. We use data from th...

In this work, we show that Kleinberg’s hubs and authorities model is closely related to both correspondence analysis, a well-known multivariate statistical technique, and a particular Markov chain model of navigation through the web. The only difference between correspondence analysis and Kleinberg’s method is the use of the average value of the hubs (authorities) scores for computing the autho...

We have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. This network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...