We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in ...

A challenge in mobile computing is to provide continuous interactions between users and their running applications. An interesting model is to allow a user's computing environment to migrate between a stationary computer and a mobile computer while applications are running. To achieve this goal, it is necessary to extend existing operating systems at several levels. This paper focuses on the pr...

When attention is diffuse, as in a visual search task, an abrupt onset almost invariably succeeds in capturing attention. But if attention had been cued in advance to a different location, the same onset may then fail to capture attention (Theeuwes, 1991; Yantis and Jonides, 1990). In previous demonstrations, the onset appeared frequently. This may have diminished the onset's novelty, which in ...

Large heterogeneity has prevented current capital structure research from explaining variations in firms’ capital structures to a satisfactory degree. We find that firms generally fall into two categories based on their capital structure policies. One category consists of larger firms that tend to pay dividends, and includes almost all zero-leverage firms in the sample. These firms tend to resp...

We present Regular-SAT, an extension of Boolean Satisfiability based on a class of many-valued CNF formulas. Regular-SAT shares many properties with Boolean SAT, which allows us to generalize some of the best known SAT results and apply them to Regular-SAT. In addition, Regular-SAT has a number of advantages over Boolean SAT. Most importantly, it produces more compact encodings that capture pro...

Acquirers can use company-specifi c synergies as a competitive advantage, particularly when they bid against private equity fi rms. Previously, private equity fi rms outbid strategic buyers by utilizing fi nancial leverage to achieve return goals. The current economic environment doesn’t enable that strategy; private equity fi rms can only embed synergies in their bid price when they merge the ...

declare that the warming world is phenomenon beyond all doubt, and that the likelihood of this being caused by the human action of putting greenhouse gases into the atmosphere — and not, say, by increased solar activity, as some have argued — is greater than 90 per cent. For all but the most perverse of sceptics, it ends the basic argument. And it also urgently warns that the risks are greater,...

Context-aware applications require context information to adapt their behaviour to the current situation. When developing context-aware applications, application developers need to transform specific application context requirements into application logic to discover, select and bind to suitable sources of context information. To facilitate the development of context-aware applications, we prop...

Why do we take pictures and videos? Often, the answer is that we hope to capture moments in time, so that we can later recall and savor them once again. Digital cameras and camcorders are making it ever easier to record these moments, but often, something is lost. Photographs freeze time and space, losing the sense of motion in a scene and losing the freedom of motion available to the original ...