Chimeric-antigen-receptor (CAR) T cells targeting CD19 show dramatic remissions in refractory or relapsed acute lymphoblastic leukemia. Interleukin-6 (IL-6) has been associated with severe cytokine release syndrome (CRS) following CAR T cell treatment, leading to significant toxicity and death. CRS could be treated with an antiIL6-receptor antibody, with reversal of most of the inflammatory res...

Freight trucks are an important component of the nation s highway traffic. Due to their physical and operational characteristics, they can significantly impact traffic system performance, safety, and the travel experience of non-truck drivers. Methodological gaps exist in the literature on modeling car–truck interactions that do not result in crashes, especially those resulting from non-truck d...

Chimeric antigen receptor (CAR) T cells can produce durable remissions in hematologic malignancies that are not responsive to standard therapies. Yet the use of CAR T cells is limited by potentially severe toxicities. Early case reports of unexpected organ damage and deaths following CAR T-cell therapy first highlighted the possible dangers of this new treatment. CAR T cells can potentially dam...

creates two interpretations. On one reading, the temporal adjective modifies the common noun (N-modifying reading). On the other, it modifies the possession relation (POSS-modifying reading). An explanation for this behavior is offered that appeals to what occurs in possessive sentences like John has a former car (N-modifying reading) and John formerly had a car (POSS-modifying reading). In the...

Heavy vehicles are significantly longer and heavier than passenger cars and consequently have quite different acceleration and braking capabilities. Heavy vehicle manoeuvres are therefore likely to influence drivers’ vehicle-following behaviour differently to cars. Heavy vehicles can also influence the behaviour of drivers of other vehicles while following a heavy vehicle. This paper used data ...