OBJECTIVE To evaluate the efficacy and safety of carbamazepine, pregabalin, and venlafaxine in patients with painful diabetic neuropathy (PDN). METHODS Our study was performed as a randomized, double-blind, parallel-group clinical trial between December 2012 and December 2013 at Kermanshah University of Medical Sciences, Kermanshah, Iran. Two hundred and fifty-seven patients with clinically d...

Lithium, valproate and carbamazepine decrease brain cAMP. Adenylyl-cyclase (AC), which synthesizes cAMP has nine membrane-bound isoforms (AC1-AC9). In this study we used COS7 cells transfected with cDNA of each of the isoforms to study the effect of a therapeutic concentration of each of lithium, carbamazepine and valproate on ACs activity. AC5 was the most inhibitable isoform by lithium and ca...

BACKGROUND Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-spec...

introduction: carbamazepine is commonly used in a variety of indications. poisoning by this drug, can lead to coma, seizures, cardiac disorders and respiratory distress. the treatment of poisoning is generally supportive. method: 68 poisoned patients with carbamazepine, who referred to poisoning ward of loghman hospital, from july 2003 to september 2004, were studied. these patients were invest...

Carbamazepine (CBZ), one of the most used pharmaceuticals worldwide and a Contaminant Emerging Concern, represents potential risk for environment human health. Wastewater treatment plants (WWTPs) are significant source CBZ to environment, polluting whole water cycle. In this review, presence fate in urban cycle addressed, with focus on adsorption as possible solution its removal. Specifically, ...

Atypical (non-Michaelis-Menten) kinetics are commonly observed with CYP3A4 substrates in vitro. If relevant in vivo, cytochrome P450 heteroactivation could give rise to increased drug clearance. To test the possible in vivo relevance of atypical cytochrome P450 kinetics, we investigated the role of heteroactivation in the therapeutically relevant drug interaction between the anti-epileptics fel...

Carbamazepine (CBZ) is the most frequently detected pharmaceutical residues in aquatic environments effluent by wastewater treatment plants. Batch and column experiments were conducted to evaluate removal of CBZ from ultra-pure water plant (WWTP) using raw zeolitic tuff (RZT) surfactant modified zeolite (SMZ). Point zero net charge (pHpzc), X-ray diffraction (XRD), fluorescence (XRF), Fourier T...

An unusual case of primary meningo-encephalitis followed by partial complex seizure in a 9-year-old boy was found to be a symptom of cerebral Bartonella henselae infection or cat scratch disease. Despite one clinical relapse at 4 weeks post-presentation, he remained seizure free on carbamazepine for one year. Six months after stopping carbamazepine, however, he developed deja vu phenomena and a...

QUESTION Some of my pregnant patients are afraid to take their antiepileptic drugs during pregnancy because of the known risk of malformations and the neurodevelopmental problems associated with valproic acid. Are there similar concerns with carbamazepine? ANSWER Similar to valproic acid, carbamazepine increases the risk of neural tube defects; however, it does not increase the risk of other ...