The intent of this review is to critically consider the data that support concept programming and its implications. Birth weight growth trajectories during childhood are associated with cardiometabolic disease in adult life. Both extremes, low high birth coupled postnatal increase early presence risk factors vascular imprinting, crucial elements framework. Data coming from epigenetics, proteomi...

The components of the metabolic syndrome, including prediabetes, prehypertension and dyslipidemia, represent prodromal stages of major cardiometabolic disorders. Lifestyle interventions have been shown to ameliorate or prevent the progression of individual components of the metabolic syndrome. The specific interventions utilized in randomized controlled studies often include dietary modificatio...

BACKGROUND The purpose of this study was to determine the sex-specific pattern of pediatric cardiometabolic risk with principal component analysis, using several biological, behavioral and parental variables in a large cohort (n = 2866) of 6th grade students. METHODS Cardiometabolic risk components included waist circumference, fasting glucose, blood pressure, plasma triglycerides levels and ...

Menopause-related hormonal changes are associated with an increased prevalence of various cardiometabolic risk factors, components of the metabolic syndrome, and an excess risk of all-cause and cardiovascular mortality. Estrogen withdrawal and the subsequent androgenicity interact in a synergistic manner to predispose post menopausal women to an increase in total body weight but also to a prono...

This study examined prepregnancy cardiometabolic risk factors and gestational diabetes mellitus (GDM) in subsequent pregnancies. The authors selected 1,164 women without diabetes before pregnancy who delivered 1,809 livebirths between 5 consecutive examinations from 1985 to 2006 in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The authors measured prepregnancy cardiometab...