ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Mustafa Aydogan and Laura Hankins are co-first on ‘ Centriole distal-end proteins CP110 Cep97 influence centriole cartwheel growth at proximal end’, JCS. now group leader Department Biochemistry Bio...

Disengagement of parent centrioles represents the licensing process to restrict centriole duplication exactly once during the cell cycle. However, we provide compelling evidence that this general rule is overridden in insect gametogenesis, when distinct procentrioles are generated during prophase of the first meiosis while parent centrioles are still engaged. Moreover, the number of procentriol...

Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles via cyclin A to negatively regulate centrosome duplication by binding and inh...

Dr. Enzinger was the primary editor of the first soft tissue World Health Organization (WHO) book in 1969, entitled “Histological Typing of Soft Tissue Tumours.” Although he had not yet described angiomatoid “malignant” fibrous histiocytoma (A(M)FH), giant cell fibroblastoma (GCF), or plexiform fibrohistiocytic tumor (PFHT), he had already considered the concept of a fibrous tumor of intermedia...

Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family. SAS-6 from Chlamydomonas reinhardtii and Danio rerio was shown to form ninefold symmetric, ring-shaped oligomers in vitro that were similar to the cartwheels observed...

Because of the availability of disease and genetic models, the mouse has become a valuable species for auditory neuroscience that will facilitate long-term goals of understanding neuronal mechanisms underlying the perception and processing of sounds. The goal of this study was to define the basic sound-evoked response properties of single neurons in the mouse dorsal cochlear nucleus (DCN). Neur...

ABSTRACT We analyse all the available Chandra observations of Cartwheel galaxy and its compact group, taken between 2001 2008, with main aim addressing variability in X-ray band for this spectacular collisional ring galaxy. focus on study point-like sources, particular we are interested ultraluminous sources (ULXs; LX ≥ 1039 erg s−1), that treat as a class. exploit archival XMM–Newton data to e...