Background. Norovirus outbreaks in schools can amplify rapidly through multiple routes of transmission, and have led to campus closures. Ensuring implementation of transmission-prevention measures is challenging in large secondary schools, where exclusion criteria for ill persons may be limited, and sufficient environmental surface disinfection may be difficult to achieve. During a norovirus ou...

Background: Conflicting results have been reported regarding the correlation of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of lung cancer as well as response to chemotherapy. Objective: To estimate the correlations of the MTHFR C677T polymorphism and risk of lung cancer as well as response to chemotherapy by conducting a meta-analysis. Methods: A comprehensi...

Recent genome-wide association studies (GWAS) have identified common genetic risk variants for chronic lymphocytic leukemia (CLL). Testing SNPs individually for an association in GWAS necessitates the imposition of a very stringent P value to address multiple testing. While this reduces false positives, it may result in true associations being missed. Thus, any overall estimate of the total her...

Phenolphthalein is frequently used laxative drug since 1930s, but the possible teratogenic effect of phenolphthalein was not checked in casecontrol eptedmiological study. In addition US Food and Drug Administration (FDA) declared the mutagenic and carcinogenic effect of phenolphthalein in 1999, thus we decided to evaluate the birth outcomes particularly congenital abnormalities (CAs) of newborn...

Early detection remains the most promising approach to improve long-term survival of patients with ovarian cancer. In a five-center casecontrol study, serum proteomic expressions were analyzed on 153 patients with invasive epithelial ovarian cancer, 42 with other ovarian cancers, 166 with benign pelvic masses, and 142 healthy women. Data from patients with early stage ovarian cancer and healthy...

Previous studies on statin have revealed that increasing age, renal insufficiency, and concomitant medications were associated with rhabdomyolysis. However, there is a lack of analysis on the magnitude of such association in the Asia-Pacific region. The objectives of this study were to identify risk factors of statin-associated rhabdomyolysis in Thai patients and to evaluate the magnitude of as...

Abstrad Adenocarcinomas of the esophagus and gastric cardia were once rare. However, for unknown reasons, their incidence has been increasing rapidly over the past 15 years in the United States and parts of Western Europe. In contrast, the incidence of esophageal squamous cell carcinomas has remained relatively constant. To investigate possible reasons for these diverging incidence rates we ana...

Weight loss is prevalent in the elderly population, with deleterious health consequences, notably loss of lean body mass and subsequent functional decline. Protein intake below the current RDA [0.8 g/(kg d)] is also common in older adults; however, the link between the 2 has received little attention. Our objective was to assess the relation between protein intake and incident 1-y weight loss $...

Introduction Low-energy distal radius fractures normally occur earlier in life than hip and spine fractures and may be the first presentation of osteoporosis. Few studies have addressed the association between distal radius fracture and osteoporosis. Vitamin D inadequacy is associated with an increased risk of hip fractures, but the association with distal radius fractures has not been explored...

OBJECTIVE: Giving recommended immunizations during sick visits for minor and acute illness such as acute otitis media has long been an American Academy of Pediatrics/Advisory Committee on Immunization Practice recommendation. An addition to the American Academy of Pediatrics policy in 2010 advised considering whether giving immunizations at the sick visit would discouragemaking upmissed well-ba...