Hepatocyte gap junction proteins, connexins (Cxs) 26 and 32, are downregulated during obstructive cholestasis (OC) and lipopolysaccharide hepatocellular cholestasis (LPS-HC). We investigated rat hepatic Cxs during ethynylestradiol hepatocellular cholestasis (EE-HC) and choledochocaval fistula (CCF) and compared them with OC and LPS-HC. Levels (immunoblotting) and cellular distribution (immunofl...

BACKGROUND Efforts have been undertaken recently to assess the fetal genome through analysis of circulating cell-free (ccf) fetal DNA obtained from maternal plasma. Sequencing analysis of such ccf DNA has been shown to enable accurate prenatal detection of fetal aneuploidies, including trisomies of chromosomes 21, 18, and 13. We sought to extend these analyses to examine subchromosomal copy num...

ogy requiring endovascular treatment. Most direct CCFs are secondary to traumatic injury involving the cavernous segment of the internal carotid artery (ICA). Rupture of an intracranial aneurysm (esp. intracavernous aneurysm) leads to CCF, epistaxis, or subarachnoid hemorrhage. On the contrary, TCAs comprise less than 1% of all intracranial aneurysms and are usually associated with penetrating ...

Introduction: Direct carotid cavernous fistulas (CCF) are abnormal communications between the internal carotid artery and the cavernous sinus usually resulting from high energy trauma to the face and base of skull. The management of direct CCF relies on endovascular procedures repairing the malformation as healing cannot take place in the high flow system. Case Report: A 16­year­old male presen...

Functional interactions between neurons in vivo are often quantified by cross-correlation functions (CCFs) between their spike trains. It is therefore essential to understand quantitatively how CCFs are shaped by different factors, such as connectivity, synaptic parameters, and background activity. Here, we study the CCF between two neurons using analytical calculations and numerical simulation...

Carotid cavernous fistulas (CCF) are vascular communications between the carotid artery and the cavernous sinus. Ophthalmologists are called to diagnose and manage the condition in cases that present with ocular features. A 73-year-old female was referred to our glaucoma center clinic. Eight years before, she had started receiving medication for glaucoma and had undergone laser iridotomy, but a...

Introduction. It is strongly advised by the European Resuscitation Council not to interrupt chest compressions for airway management. An alternative to tracheal intubation is the use of a supraglottic airway device (SAD) which should shorten “hands-off” time during cardiopulmonary resuscitation (CPR). Chest compression fraction (CCF) should be above 0.6 to ensure the probability of successful C...

We present a mechanism for computing asymptotically stable school optimal matchings, while guaranteeing that it is an asymptotic dominant strategy for every student to report their true preferences to the mechanism. Our main tool in this endeavor is differential privacy: we give an algorithm that coordinates a stable matching using differentially private signals, which lead to our truthfulness ...

Auction theory traditionally assumes that bidders’ valuation distributions are known to the auctioneer, such as in the celebrated, revenue-optimal Myerson auction [Myerson, 1981]. However, this theory does not describe how the auctioneer comes to possess this information. Recently, Cole and Roughgarden [2014] showed that an approximation based on a finite sample of independent draws from each b...

The Gromov-Hausdorff distance is a natural way to measure distance between two metric spaces. We give the first proof of hardness and first non-trivial approximation algorithm for computing the Gromov-Hausdorff distance for geodesic metrics in trees. Specifically, we prove it is NP-hard to approximate the Gromov-Hausdorff distance better than a factor of 3. We complement this result by providin...