The expansion of wavefront-sensing techniques redefined the meaning of refractive error in clinical ophthalmology. Clinical aberrometers provide detailed measurements of the eye's wavefront aberration. The distribution and contribution of each higher-order aberration to the overall wavefront aberration in the individual eye can now be accurately determined and predicted. Using corneal or ocular...

PURPOSE To assess the compensation of total ocular and corneal wavefront aberrations after conventional myopic LASIK. METHODS This study comprised 57 eyes of 57 patients. Total and corneal aberrations were measured preoperatively and 3 months postoperatively using the OPD-Scan (NIDEK Co Ltd) aberrometer. Total and corneal aberrations root-mean-square (RMS) was calculated out to the 6th Zernik...

During the last decade aberration correction became possible for several types of electron optical instruments. Correctors for the spherical aberration of TEM / STEM objective lenses are now commercially available [1,2]. In case of the SEM [3] and the LEEM / PEEM [4] the correction of both the spherical and the chromatic aberration has been demonstrated in experiments. In spite of these great a...

PURPOSE The aim of this study was to design and evaluate in the laboratory a new intraocular lens (IOL) intended to provide superior ocular optical quality by reducing spherical aberration. METHODS Corneal topography measurements were performed on 71 cataract patients using an Orbscan I. The measured corneal surface shapes were used to determine the wavefront aberration of each cornea. A mode...

PURPOSE To compare the effect of spherical aberration on optical quality in eyes with two different aspherical intraocular lenses. METHODS 120 eyes of 60 patients underwent phacoemulsification. In patients' eyes, an aberration-free IOL (Aspira-aA; Human Optics) or an aberration-correcting aspherical IOL (Tecnis ZCB00; Abott Medical Optics) was randomly implanted. After surgery, contrast sensi...

Amplification of the c-myc gene has been reported in non-small cell lung cancer(NSCLC). We performed dual color fluorescence in situ hybridization(FISH)to detect amplifications of the c-myc gene on chromosome 8 to evaluate the relationship between these possible abnormalities and pathological stage. Tumor tissue samples were obtained from 29 patients of NSCLC in Stage I(n=15)and III(n=14)who un...

Amplification of the c-myc gene has been reported in non-small cell lung cancer (NSCLC). We performed dual color fluorescence in situ hybridization (FISH) to detect amplifications of the c-myc gene on chromosome 8 to evaluate the relationship between these possible abnormalities and pathological stage. Tumor tissue samples were obtained from 29 patients of NSCLC in Stage I (n = 15) and III (n =...

Analysis of cell-free DNA using next-generation sequencing (NGS) is a powerful tool for the detection/monitoring of alterations present in circulating tumor DNA (ctDNA). Plasma extracted from 171 patients with a variety of cancers was analyzed for ctDNA (54 genes and copy number variants (CNVs) in three genes (EGFR, ERBB2 and MET)). The most represented cancers were lung (23%), breast (23%), an...