نتایج جستجو برای: cell cycle arrest

تعداد نتایج: 1892052  

2014
Chao-Ming Hung Chi-Chang Chang Chen-Wei Lin Chih-Chen Chen Yi-Chiang Hsu

Nasopharyngeal carcinoma (NPC) is a common form of malignant cancer, for which radiotherapy or chemotherapy are the main treatment methods. Cucurbitacin E (CuE) is a natural compound-based drug which from the climbing stem of Cucumic melo L (Guadi). Previously shown to be an antifeedant as well as a potent chemopreventive agent against several types of cancer. The present study, investigated an...

Masoomeh Aghababazadeh Mohammad Amin Kerachian,

  Humans suffer transient or persistent starvation due to a lack of food intake, either because of fasting, voluntary dieting, or due to the scarcity of available food. At the cellular level it is possible to possess pathological starvation during ischemia and solid tumors. Blood provides many nutrients to our cells, and researchers provide these nutrients to cells in culture in the form of en...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1998
Y D Yoo J K Park J Y Choi K H Lee Y K Kang C S Kim S W Shin Y H Kim J S Kim

Paclitaxel induces a cell cycle block at G2-M phase by preventing the depolymerization of microtubules and induces p53-independent apoptosis in many cancer cells. We observed that gastric cancer cells treated with paclitaxel have shown a cyclin-dependent kinase (CDK)4 down-regulation. This paclitaxel-induced CDK4 down-regulation resulted in a cell cycle arrest at G1-S phase. To confirm this obs...

2010
Stacey E. Wirt Adam S. Adler Véronique Gebala James M. Weimann Bethany E. Schaffer Louis A. Saddic Patrick Viatour Hannes Vogel Howard Y. Chang Alex Meissner Julien Sage

The ability of progenitor cells to exit the cell cycle is essential for proper embryonic development and homeostasis, but the mechanisms governing cell cycle exit are still not fully understood. Here, we tested the requirement for the retinoblastoma (Rb) protein and its family members p107 and p130 in G0/G1 arrest and differentiation in mammalian cells. We found that Rb family triple knockout (...

Journal: :Cell 2014
Bao N. Puente Wataru Kimura Shalini A. Muralidhar Jesung Moon James F. Amatruda Kate L. Phelps David Grinsfelder Beverly A. Rothermel Rui Chen Joseph A. Garcia Celio X. Santos SuWannee Thet Eiichiro Mori Michael T. Kinter Paul M. Rindler Serena Zacchigna Shibani Mukherjee David J. Chen Ahmed I. Mahmoud Mauro Giacca Peter S. Rabinovitch Aroumougame Asaithamby Ajay M. Shah Luke I. Szweda Hesham A. Sadek

The mammalian heart has a remarkable regenerative capacity for a short period of time after birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to determine the primary postnatal event that results in cardiomyocyte cell-cycle arrest. We hypothesized that transition to the oxygen-rich postnatal environment is the upstream signal that results in cell-cycle arr...

Journal: :Investigative Opthalmology & Visual Science 2008

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