objective: to study the mechanisms involved in amyloid formation processes, we made a mammalian cell culture model of amylin aggregation and characterized its properties. materials and methods: amyloid fibrils were extracted from cho cells and binding affinity to thioflavin t and congo red was investigated. then the apple-green birefringence of extracted fibrils was detected under polarized li...

Cell formation considering the availability of alternative routings and the processing capacity of available machines is a challenging optimization problem, since it imposes the solution of a two step problem: i) assign machines to cells; and ii) assign manufacturing parts (routings) to cells. The objective is to minimize extra-cellular processing of tasks when routings of parts are selected. A...

Group technology (GT) is a useful way to increase productivity with high quality in cellular manufacturing systems (CMSs), in which cell formation (CF) is a key step in the GT philosophy. When boundaries between groups are fuzzy, fuzzy clustering has been successfully adapted to solve the CF problem; however, it may result uneven distribution of parts/machines where the problem becomes larger. ...