نتایج جستجو برای: cell genomics
تعداد نتایج: 1708627 فیلتر نتایج به سال:
A revolution in cellular measurement technology is under way: For the first time, we have the ability to monitor global gene regulation in thousands of individual cells in a single experiment. Such experiments will allow us to discover new cell types and states and trace their developmental origins. They overcome fundamental limitations inherent in measurements of bulk cell population that have...
abstract background and objective: paratuberculosis is a chronic granulomatous enteritis of ruminants caused by mycobacterium avium subspecies paratuberculosis (map). this study aimed to characterize the genome of the map 316f strain. methods: the map 316f strain was subjected to the pcr-f57 and pcr-is900 experiments in order to ensure its identity as map. this was followed by appl...
Genetical genomics is a strategy for mapping gene expression variation to expression quantitative trait loci (eQTLs). We performed a genetical genomics experiment in four functionally distinct but developmentally closely related hematopoietic cell populations isolated from the BXD panel of recombinant inbred mouse strains. This analysis allowed us to analyze eQTL robustness/sensitivity across d...
James D. Watson Institute of Genome Sciences, Zhejiang University and Hangzhou Genomics Institute, Zhejiang Provincial Key Laboratory of Genomic Bioinformatics, Hangzhou 310008, China (X.T., S.H., J.Y.); Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China (X.T., S.H., J.Y.); College of Life Science, Zhejiang University, Hangzhou 310027, China (X.T., J.Z.); and Shan...
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity of Th17 cells isolated from the central nervous system (CNS) and lymph nodes (LN) at the peak of...
Background The complexity of subcortical brain remains unexplored due to complex neuronal structure and heterogeneity populations in the brain. Raphe regulates multiple physiological events like stress, memory, feeding, sleep, movement, balance, many others. ere we present single cell RNAsec (scRNAseq) analysis raphe tissue from postmortem brains Alzheimer’s disease Braak Stages VI control subj...
Context: Since most scientists tend to investigate live biological samples, there is inadequate data on efficient molecular techniques for the anthropological sciences. In this short review, multiple methods were mentioned and compared provide a brief insight into application of genomics proteomics post-mortal specimen. Evidence Acquisition: Through use proper keywords, PubMed Elsevier database...
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