Aptamers are single-stranded DNA or RNA oligonucleotides or peptides that are capable of binding to specific target proteins. Aptamers are generated in a process named SELEX or cell-SELEX. They resemble antigens in respect of their highly specific binding in the lower nanomolar and/or picomolar range. In contrast to antibodies, they can be generated in vitro, are more stable molecules and have ...

Aptamers are single-stranded DNA or RNA oligonucleotides or peptides that are capable of binding to specific target proteins. Aptamers are generated in a process named SELEX or cell-SELEX. They resemble antigens in respect of their highly specific binding in the lower nanomolar and/or picomolar range. In contrast to antibodies, they can be generated in vitro, are more stable molecules and have ...

Currently, the development of effective diagnostic reagents as well as treatments against Hepatitis C virus (HCV) remains a high priority. In this study, we have described the development of an alive cell surface--Systematic Evolution of Ligands by Exponential Enrichment (CS-SELEX) technique and screened the functional ssDNA aptamers that specifically bound to HCV envelope surface glycoprotein ...

development of potent new anti-shigella agents for rapid and specific detection and treatment is of great importance. aptamers, nucleic acid oligomers capable of specific binding to a wide range of non-nucleic acid targets, may be of value for this purpose. in the present study, we used a systematic evolution of ligands by exponential enrichment (selex) process to select dna aptamers that b...

Aptamers are small nucleic acid ligands that bind to their targets with specificity and high affinity. They are generated by a combinatorial technology, known as SELEX. This in vitro approach uses iterative cycles of enrichment and amplification to select binders from nucleic acid libraries of high complexity. Here we combine SELEX with the yeast three-hybrid system in order to select for RNA a...

The SELEX experiment (E781) is a 3-stage magnetic spectrometer for a high statistics study of hadroproduction of charm baryons out to large xF using 650 GeV Σ,π and p beams. The main features of the spectrometer are: a high precision silicon vertex system; powerful particle identification provided by TRD and RICH; forward Λs decay spectrometer; and 3-stage lead glass photon detector. Preliminar...