PURPOSE The objective of this study was to explore whether killer immunoglobulin-like receptor (KIR) genotypes and haplotypes are associated with dry eye disease (DED) in a Han Chinese population. METHODS Polymerase chain reaction with sequence-specific primers (PCR-SSP) method was used to genotype KIR genes in 106 patients with DED and 220 healthy controls. RESULTS Twenty-three KIR genotyp...

With the aim of clarifying the role of several polymorphisms around the HLA-C locus in the clinical expression of PsA, the distribution of several polymorphic markers and genes located around the HLA-C locus was analyzed in a well-established cohort of 110 patients with PsA, 50 patients with psoriasis alone, and 110 healthy controls. The frequency of these genes was also analyzed by PsA articul...

Karyotyping, a standard method for presenting pictures of the human chromosomes for diagnostic purposes, is a long standing, yet common technique in cytogenetics. Automating the chromosome classification process is the first step in designing an automatic karyotyping system. The main aim in this study was to define a new group of features for better representation and classification of chromoso...

Main results Overall, 300 people had died from probable suicide at the time of follow up. Within one year of index episode: The overall risk of probable suicide was 0.7% (95% CI 0.6% to 0.9%). In males, the risk was 1.1% (95% CI 0.8 to 1.5). In females, the risk was 0.5% (95% CI 0.4 to 0.7). Within 15 years of index episode: The overall risk of probable suicide was 3.0% (95% CI 2.6 to 3.4). In ...

conclusions our study showed that the persian version of yiat is good and usable on iranian people. the reliability of the instrument was very good. moreover, the validity of the persian translated version of the scale was sufficient. in addition, the reliability and validity of the three extracted factors of yiat were evaluated and were acceptable. results the cronbach’s alpha was 0.917 (ci 95...

purpose: the objective of this study was to identify possible risk factors associated with primary open-angle glaucoma (poag). methods: a case-control study included patients seen at rasoul-akram hospital ophthalmology clinic. cases were consecutive patients with confirmed unilateral or bilateral poag presented during the study period. controls were a random sample of all other patients aged 30...

Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited familial cancer syndrome characterised by a predisposition to the development of retinal, cerebellar, and spinal haemangioblastomas, renal cell carcinoma, and phaeochromocytoma. The gene for VHL disease has been mapped to chromosome 3p25-p26 and flanking markers identified. We report the detailed genetic mapping of the VHL disea...