BACKGROUND Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant cerebellar ataxia caused by CAG trinucleotide expansion. The characteristics of regional cerebral blood flow (rCBF) in SCA6 patients have not been established, whereas it has been reported that decreased rCBF in the cerebrum seems to be a remote effect of cerebellar impairment in other cerebellar disorders. OBJECTIVE To ...

Early investigations of cerebellar function focused on motor learning, in particular on eyeblink conditioning and adaptation of the vestibulo-ocular reflex, and led to the general view that cerebellar long-term depression (LTD) at parallel fiber (PF)-Purkinje cell (PC) synapses is the neural correlate of cerebellar motor learning. Thereafter, while the full complexity of cerebellar plasticities...

In human and non-human primates, motor timing is considered to be dictated by cerebellar control of cortical activity, relayed through the cerebellar-thalamo-cortical (CTC) system. This supposition relies on studies that documented impairments in patients animal models. However, we know very little about way information integrated circuitry affect commands. We addressed this question probing CT...

Introduction: Purkinje Cell (PC) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. Riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. Here, the spectral analysis of PCs firing in control, 3-acety...

Six dogs with cerebellar dysplasia, in which the cerebellar vermis was hypoplastic, are described. Clinical signs in these dogs were noted around 2 weeks of age and included ataxia, dysmetria, and intention tremors. A variable portion of the caudal cerebellar vermis was absent in each dog; portions of the cerebellar hemispheres and flocculus also were absent in some of them. Neurons in certain ...

= Abstract = We herein report an elderly patient with cryptococcosis in the nervous system who presented with cerebellar dysfunction and showed cerebellar parenchymal lesion with adjacent focal meningeal enhancement on the brain CT and the serial brain MRIs. The cerebellar lesion suggests cryptococcal inflammatory reaction or a cerebellar infarction from the arteritis of a branch of the left su...

Prenatal diagnosis of congenital and acquired cerebellar disorders is possible by the use of ultrasound (US) and magnetic resonance imaging (MRI). Although numerous studies have been conducted in this field, diagnostic uncertainties are still common in daily clinical practice. This review outlines five possible pitfalls in the diagnosis of fetal cerebellar disorders: confusion between different...

OBJECTIVE To explore the lesion patterns and stroke mechanism of the acute bilateral cerebellar infarct. PATIENTS AND METHODS Patients admitted to Xiangyang Hospital with acute cerebellar infarcts, confirmed by diffusion-weighted imaging (DWI), were investigated. Patients were divided into two groups by lesions: unilateral cerebellar infarct (UCI) and bilateral cerebellar infarct (BCI). The d...

Two patients with a severe cerebellar syndrome due to chronic bromisovalum usage are described. In both patients CT scan revealed severe cerebellar atrophy. The value of computed tomography in detecting irreversible cerebellar lesions due to bromisovalum is discussed.