نتایج جستجو برای: cerebral amyloid angiopathy
تعداد نتایج: 216703 فیلتر نتایج به سال:
Senile plaques are mainly composed of different species of fibrillar β-amyloid (Aβ), a product of the cleavage of the β-amyloid precursor protein (APP), and they are surrounded by dystrophic neurites, reactive astrocytes and microglia. Aβ fibrillar deposits also occur in diffuse plaques, subpial deposits and in the wall of the cerebral and meningeal blood vessels in the form of amyloid angiopat...
A case of cerebral amyloid angiopathy associated with granulomatous arteritis is presented with description of the microscopic, immunocytochemical and ultrastructural features. The amyloid proved to be of the AL-type, with failure to show reactivity with anti-AA, anti-prealbumin and anti-albumin. Antisera against SAP and IgG (AF) did show reactivity. Hence the immunologic characteristics of thi...
From the Experimental Genetics Group,* Center for Human Genetics, Flemish Institute for Biotechnology, the Center for Transgene Technology and Gene Therapy, Center for Molecular and Vascular Biology, and Genetic Epidemiology, K.U.Leuven, Leuven, Belgium; the Janssen Research Foundation, Beerse, Belgium; Innogenetics, Gent, Belgium; Institut de Pharmacology Moléculaire et Cellulaire/CNRS, Valbon...
The authors describe three patients with reversible leukoencephalopathy associated with cerebral amyloid angiopathy (CAA). Rapid progression of neurologic symptoms was followed by dramatic clinical and radiographic improvement. Pathologically, CAA was associated with varying degrees of inflammation ranging from none to transmural granulomatous infiltration. In the appropriate clinical context, ...
BACKGROUND Magnetic resonance imaging-visible perivascular spaces (PVS) are related to interstitial fluid clearance pathways (including amyloid-β) in the brain and are suggested to be a marker of cerebral small vessel disease. We investigated the role, topography, and possible implications of PVS in cognitive impairment. METHODS AND RESULTS A total of 1504 patients undergoing memory clinic in...
Hereditary cerebral hemorrhage with amyloidosis - Dutch type is an autosomal dominant hereditary disease caused by a point mutation in the amyloid precursor protein gene on chromosome 21. The mutation causes an amino acid substitution at codon 693 (E22Q), the 'Dutch mutation'. Amyloid β, the product after cleavage of the amyloid precursor protein, is secreted into the extracellular space. The D...
See related article, pages 2894–2897. In this issue of Stroke, Feldman and coworkers1 describe 3 subjects with clinically somewhat atypical Alzheimer Disease (AD) and with a radiologically verified superficial siderosis (SS). In 2 of these patients, a neuropathological examination confirmed AD with concomitant cerebral amyloid angiopathy (CAA) and a premortem diagnosis of SS. Thus, a linkage wa...
Cerebral amyloid angiopathy (CAA) is increasingly recognized as a major contributor of Alzheimer's disease (AD) pathogenesis. To date, vascular deposits and not parenchymal plaques appear more sensitive predictors of dementia. Amyloid deposition in and around cerebral blood vessels plays a central role in a series of response mechanisms that lead to changes in the integrity of the blood-brain b...
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