Introducción: el desarrollo de nuevas tecnologías diagnóstico molecular ha permitido la detección numerosas alteraciones del genoma involucradas en inicio y progresión cáncer. Desempeña un rol importante identificación variantes utilidad clínica o mutaciones accionables, entendidas como aquellas puntuales que permiten guiar las decisiones terapéuticas con inhibidores dirigidos a estos blancos m...

The type-2 (AT(2)) angiotensin (Ang) II receptor has been characterized as potentially counterregulatory to the actions of Ang II at its type-1 (AT(1)) receptor. We investigated the effects of Ang II and CGP-42112A (CGP), a selective peptide AT(2) receptor agonist, on blood pressure (BP) in rats with or without pharmacological blockade of the AT(1) receptor with losartan (LOS) or valsartan (VAL...

This article constructed a four-level fresh agricultural product (FAP) supply chain with two-stage pricing strategy under “community group purchase (CGP) platform + direct procurement from the FAP supplier” sales model. We investigate influence of CGP agency’s participation in control freshness preservation efforts on profits stakeholders. discusses effects supplier profit-sharing ratio, agency...

This paper introduces an extension to Cartesian Genetic Programming (CGP), aimed at image classification problems. Individuals in the population consist of two layers of functions: image processing functions, and traditional mathematical functions. Information can be passed between these layers, and the final result can either be an image or a numerical value. This has been applied to image cla...

This paper formally introduces Recurrent Cartesian Genetic Programming (RCGP), an extension to Cartesian Genetic Programming (CGP) which allows recurrent connections. The presence of recurrent connections enables RCGP to be successfully applied to partially observable tasks. It is found that RCGP significantly outperforms CGP on two partially observable tasks: artificial ant and sunspot predict...

A new class of FPGA-based accelerators is presented for Cartesian Genetic Programming (CGP). The accelerators contain a genetic engine which is reused in all applications. Candidate programs (circuits) are evaluated using application-specific virtual reconfigurable circuit (VRC) and fitness unit. Two types of VRCs are proposed. The first one is devoted for symbolic regression problems over the ...

We endow a non-semisimple category of modules unrolled quantum $${\mathfrak {sl}(2)}$$ with Hermitian structure. also prove that the CGP TQFT constructed in arXiv:1202.3553 using this is Hermitian. This gives rise to projective representations mapping class group indefinite unitary matrices.

Whole-cell patch clamp recording from cultured hippocampal neurones was used to investigate the NMDA antagonistic effects of the glycineB antagonist 5,7-DCKA and the competitive antagonist CGP 37849. Extracellular field potential recording from area CA1 of hippocampal slices was used to investigate their effects on the induction of LTP and hypoxia/hypoglycaemia-induced suppression of fEPSPs. Ad...