A novel mutation in the P2Y 12 receptor and a function-reducing polymorphism in protease-activated receptor 1 in a patient with chronic bleeding. In this issue of Blood, Belay et al present evidence of human bipotent erythroid-megakaryocyte precursor cells that can bypass the burst-forming unit-erythroid (BFU-E) and colony-forming unit-erythroid (CFU-E) stages and directly and rapidly different...

Continuous glucose sensors (CGS) offer the potential to greatly change the lives of people with diabetes. Even though two of these systems (Guardian RT, Medtronic, Northridge, CA, and DexCom STS, DexCom, San Diego, CA) have been approved by the Food and Drug Administration for use as adjuncts to self-blood glucose monitoring (SBGM), questions remain concerning the accuracy of these devices. Whe...

This paper presents our recent efforts, ZenLDA, an efficient and scalable Collapsed Gibbs Sampling (CGS) system for Latent Dirichlet Allocation (LDA) training, which is thought to be challenging that both data parallelism and model parallelism are required because of the Big sampling data with up to billions of documents and Big model size with up to trillions of parameters. ZenLDA combines bot...

Compact groups (CGs) of galaxies offer an exceptional laboratory for the study of dense galaxian environments — where interactions, tidally induced activity, and mergers are expected to be at their highest rate of occurrence. Here, we present first results from a new catalogue of compact groups, one based upon the Las Campanas Redshift Survey (LCRS). Using the equivalent width of [O II] λ 3727,...

In this study we evaluated the role of thromboxane in causing allergen-induced early and late asthmatic responses and airway hyperresponsiveness in asthmatic subjects. Twelve atopic subjects with stable asthma and documented early and late asthmatic responses to an inhaled allergen were treated with placebo or CGS 13080, a specific thromboxane synthetase inhibitor, given orally (200 mg four tim...

[1] Charge moment change (DMQ) data were examined for 41 positive cloud‐to‐ground (+CG) lightning discharges that were parents of transient luminous events (TLEs; mainly sprites) over two different storms: 9 May (20 parents) and 20 June 2007 (21). Data were broken down by contributions from the impulse DMQ (iDMQ), within the first 2 ms of the return stroke, and the DMQ from the continuing curre...

Graphical Markov models use graphs, either undirected, directed, or mixed, to represent possible dependences among statistical variables. Applications of undirected graphs (UGs) include models for spatial dependence and image analysis, while acyclic directed graphs (ADGs), which are especially convenient for statistical analysis, arise in such fields as genetics and psychometrics and as models ...

The median preoptic nucleus (MnPN) and the ventrolateral preoptic area (VLPO) are two hypothalamic regions that have been implicated in sleep regulation, and both nuclei contain sleep-active GABAergic neurons. Adenosine is an endogenous sleep regulatory substance, which promotes sleep via A1 and A2A receptors (A2AR). Infusion of A2AR agonist into the lateral ventricle or into the subarachnoid s...

The effects of the benzodiazepine receptor antagonists flumazenil (10, 20, and 30 mglkg) and CGS 8216 (10, 20, and 30 mglkg), the benzodiazepine receptor inverse-agonist methyl {3-carboline3-carboxylate ({3-CCM; 0.3, 0.6, and 1.0 mglkg), and the benzodiazepine receptor agonist diazepam (3 mglkg) were investigated on spatial learning in the Morris water maze and thigmotaxia in an open field. Flu...

Thirty-one postmenopausal women with advanced breast cancer have been treated with the nonsteroidal competitive aromatase inhibitor CGS 16949A at p.o. doses of 0.3, 1, and 2 mg twice a day. All patients were assessed for response. Five patients, all treated with 1 mg twice daily, had objective evidence of response (two complete responses and three partial responses); disease stabilized in 17 pa...