The affinity between a chosen target protein and small molecules is a key aspect of drug discovery. Screening by popular NMR methods such as Water-LOGSY suffers from low sensitivity and from false positives caused by aggregated or denatured proteins. This work demonstrates that the sensitivity of Water-LOGSY can be greatly boosted by injecting hyperpolarized water into solutions of proteins and...

BACKGROUND Minimotifs are short contiguous peptide sequences in proteins that are known to have a function in at least one other protein. One of the principal limitations in minimotif prediction is that false positives limit the usefulness of this approach. As a step toward resolving this problem we have built, implemented, and tested a new data-driven algorithm that reduces false-positive pred...

This study reports the use of an agglutination test as a routine diagnostic aid for tuberculosis. We have found this to be both useful and reliable in clinical practice. The overall reliability was greater than 90%, 13 false results being obtained in the 222 patients tested. False negatives (4) were less common than false positives (9). The major advantage of the test is its speed, serological ...

Abstract The moisture contents of sugi ( Cryptomeria japonica ), todomatsu Abies sachalinensis ) and hinoki Chamaecyparis obtusa logs were estimated using a method content estimation proposed in our previous study. In the course estimation, it was revealed that regression line correlation between specific dynamic Young’s modulus E / ρ tangent loss (tan δ green wood different from moisture-condi...

Abstract The sapwood and heartwood of plantation sugi wood ( Cryptomeria japonica ), hinoki Chamaecyparis obtusa ) were flat-sawn into timbers, then kiln-dried to a MC level below 12%. These timbers further processed specific sizes wetted on the surfaces, preheated at 150 °C radially compressed sandwich timbers. Density distribution, layer(s) position thickness, surface hardness investigated. I...

False Discovery Rate–Adjusted Multiple Confidence Intervals for Selected Parameters Yoav Benjamini and Daniel Yekutieli Yoav Benjamini is Professor and Daniel Yekutieli is Lecturer , Department of Statistics and Operations Research, School of Mathematical Sciences, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel. This research was supported by the FIRST Foundation of th...