In this report a resume is given of a series of experimental studies carried out in rabbits to develop effective local prophylactic agents against syphilis transmitted by application of a spirochaetal emulsion to the penile mucous membrane (Table). These studies were made at the Venereal Disease Research Laboratory of the United States Public Health Service between 1941 and 1946. The developmen...

You have accessJournal of UrologyHistory Urology Forum I (HF01)1 Sep 2021HF01-12 UNITED STATES HEALTH DEPARTMENT IMMORAL EXPERIMENTS IN 1940s GUATEMALA: JOHN CUTLER'S TRAINING GROUND FOR UNETHICAL STUDIES ON SEXUALLY TRANSMITTED INFECTIONS Jane Kurtzman, Ruth Blum, and Steven Brandes KurtzmanJane Kurtzman More articles by this author , BlumRuth Blum BrandesSteven View All Author Informationhttp...

Circumcision of males represents a surgical "vaccine" against a wide variety of infections, adverse medical conditions and potentially fatal diseases over their lifetime, and also protects their sexual partners. In experienced hands, this common, inexpensive procedure is very safe, can be pain-free and can be performed at any age. The benefits vastly outweigh risks. The enormous public health b...

The incidence of lymphogranuloma venereum (LGV) is low in the western world. Early LGV is characterised by bubonic disease following a painless papule or small ulcer. We report a white bisexual male who presented with a painful perianal ulcer, inguinal lymphadenitis, and concomitant infection with human immunodeficiency virus 1 (HIV-1). Chlamydia trachomatis serovar L2 was identified as the cau...

Three of 19 strains of Haemophilus ducreyi, isolated during a recent outbreak of chancroid, were found to produce beta-lactamase and to harbor a 6.0 x 10(6)-dalton plasmid. Escherichia coli transformed with this plasmid acquired beta-lactamase-mediated resistance to ampicillin. The guanine-plus-cytosine content of the plasmid was found to be 41 mol%. Restriction endonuclease digestion studies s...

We examined 300 strains of Neisseria gonorrhoeae and 100 strains of Haemophilus ducreyi to determine their in vitro susceptibility to two new cephalosporins, cefetamet (Ro 15-8074) and ceftetrame (Ro 19-5247; T-2588), and a new fluroquinolone, fleroxacin (Ro 23-6240; AM-833). Their activity was compared with that of ceftriaxone, penicillin, spectinomycin, tetracycline, and erythromycin. Cefetam...