نتایج جستجو برای: charcot
تعداد نتایج: 4654 فیلتر نتایج به سال:
BACKGROUND A substantial impediment to progress in trials of new therapies in neuromuscular disorders is the absence of responsive outcome measures that correlate with patient functional deficits and are sensitive to early disease processes. Irrespective of the primary molecular defect, neuromuscular disorder pathological processes include disturbance of intramuscular water distribution followe...
BACKGROUND Gross deformity of the foot in Charcot neuroarthropathy can lead to foot collapse and subsequent ulceration, infection, amputation, or premature death. Total-contact casting (TCC) is a well-established treatment for neuropathic diabetic plantar foot ulcers. It was hypothesized that arthrodesis plus TCC may have advantages over TCC alone. This pilot study compared the effectiveness of...
BACKGROUND High dose oral ascorbic acid substantially improved myelination and locomotor function in a Charcot-Marie-Tooth type 1A mouse model. A phase II study was warranted to investigate whether high dose ascorbic acid also has such a substantial effect on myelination in Charcot-Marie-Tooth type 1A patients and whether this treatment is safe. METHODS Patients below age 25 years were random...
INTRODUCTION Charcot foot is a relatively uncommon complication of diabetes but one which can lead to chronic ulceration, marked deformity and amputation. Although its aetiology is not fully understood, several advances have occurred in its management. Surgery has a definite role to play but the mainstay of initial treatment is non-operative. Correct diagnosis can prevent progressive deformity....
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