Identification of raw plant material intended for use in the manufacture of pharmaceuticals, excipients, or dietary supplements is carried out by examining the morphological and histological features of the article under test and by performing diagnostic chemical tests on the article. The botanical and chemical characteristics of the test article are then compared to the known botanical and che...

Owing to their inherent extraordinary thermal and biological stability and their small size, cystine-knot microproteins provide attractive scaffolds for the development of peptide-based pharmaceuticals. They are readily accessible through recombinant bacterial production or solid phase chemical synthesis. Highly potent and selective microproteins with predefined binding characteristics have bee...

Optimizing chemical structures to create potentially safe drugs during discovery and early development relies on a combination of predictive algorithms, screening, formal toxicology studies, and early clinical trials. Early in the process three critical questions emerge that must be answered by a detailed "profiling" approach. These questions are: 1) is there a correlation between the chemical ...

Accepted 25 December 2006 Revised 20 March 2006 Received 26 July 2005 Indian J. Pharm. Sci., 2006, 68 (6): 819-821 B Anal. Technol. Biomed. Life Sci., 2003, 798, 167. 6. Liang, H. P., J. Chromatogr., B Anal. Technol. Biomed. Life Sci., 2002, 77, 53. 7. Bakshi, M., Singh, B. and Singh, A., J. Chromatogr., B Anal. Technol. Biomed. Life Sci., 2001, 26, 891. 8. Salgado, H.R. and Oliveira, C.L., Pha...

Some surfactants widely used as additives in food, pharmaceuticals, and cosmetic formulations are susceptible to peroxidation resulting in accumulation of hydroperoxides (HP). Our investigation was aimed to study the possible influence of different surfactants on the proportionality and reproducibility of the ferrous oxidation-xylenol orange method developed originally for the determination of ...

Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral ro...

In 1987, a group infection of hepatitis in patients receiving a contaminated fibrinogen product was first reported to the Japanese regulatory agency. Eventually, this serious drug incident involved more than 10,000 cases of infection. In response, the Government of Japan established a responding inspection committee in 2008 to make recommendations for the restructuring of drug regulatory admini...

AIM This study aimed at documenting products used as traditional eye medicine (TEM) in Misungwi district, Tanzania, and performing preliminary analysis on safety status. METHODOLOGY Ethnomedical study was conducted in Misungwi district. Information was sourced by face-to-face interview with traditional healers, traditional medicine vendors, and knowledgeable people guided by a well-structured...

Chitin deacetylases have been identified in several fungi and insects. They catalyse the hydrolysis of N-acetamido bonds of chitin, converting it to chitosan. Chitosans, which are produced by a harsh thermochemical procedure, have several applications in areas such as biomedicine, food ingredients, cosmetics and pharmaceuticals. The use of chitin deacetylases for the conversion of chitin to chi...

Many pharmaceutical products find their way into receiving waters, giving rise to concerns regarding their environmental impact. A procedure was proposed that enables ranking of the hazard to aquatic species and human health due to such products. In the procedure, hazard assessment is based on five of the pharmaceutical product's individual physico-chemical properties. These properties are aggr...