Previous studies indicate that organ fibroblasts play an important role in wound healing, collagen production, remodeling processes and pathogenesis of progressive heart, lung, renal and hepatic fibrotic diseases. Several studies suggest a possible inhibitory role for adenosine in the regulation of fibroblast proliferation. The effect of adenosine A2 agonists on proliferation and differentiatio...

BACKGROUND In this feasibility study, a mechanically loaded in-vitro tissue culture model of joint morphogenesis using the isolated lower extremity of the 8 day old chick embryo was developed to assess the effects of mechanical loading on joint morphogenesis. METHODS The developed in-vitro system allows controlled flexion and extension of the chick embryonic knee with a range of motion of 20 ...

Chick embryos were removed from the egg at stages 6-11 and explanted in culture. The greater part of the postnodal primitive streak of each embryo was replaced with a similar region taken from a corresponding quail embryo. The reciprocal experiment was also carried out, chick primitive streak being grafted in place of quail. After further incubation, the grafted primitive streak cells were foun...

Inoculation of the Jensen rat sarcoma into the developing chick embryo gives a rapidly growing tumor at the site of inoculation, whether in the membranes or in the body of the chick itself. These tumors by transfer from embryo to embryo can be kept going for as long as forty-six days, and perhaps indefinitely in the foreign species. The rat cells show no morphological change even after a very l...

The RNA-P and DNA-P content of the nucleus and the RNA-P content of the whole cell of the livers of 8to 20-day chick embryos and of adult fowls have been determined. The DNA-P content of the liver nuclei was slightly higher in the 8and 10-day embryo than in all the other stages examined. A significant decrease in the RNA content of the cell occurred during embryonic development. The RNA content...