background and objective: in iran, prenatal chlamydia and gonorrhea screening of pregnant women and neonatal eye prophylaxis are not routine practice. the present research aimed to identify bacterial agents of neonatal conjunctivitis. materials & methods: a cross sectional study was conducted on all babies born over a period from april 2007 to april 2008 in hajar hospital of shahrekord uni...

The cytokine gamma interferon (IFN-γ) induces cell-autonomous immunity to combat infections with intracellular pathogens, such as the bacterium Chlamydia trachomatis The present study demonstrates that IFN-γ-primed human cells ubiquitinate and eliminate intracellular Chlamydia-containing vacuoles, so-called inclusions. We previously described how IFN-γ-inducible immunity-related GTPases (IRGs) ...

background: chlamydia trachomatis is considered as an important cause of preventable sexually transmitted diseases worldwide. it is known to be of an obligate intracellular nature and enters its target cells via an endocytic process. as major outer membrane protein (momp) is one of the main candidates for the attachment and entry of chlamydia to the host cells we have tried to label the epitope...

non-gonococcal infections causes are made up of chlamydia trachomatis (one of the most common infection non-gonococcal), ureaplasma urealyticum (a possible causal in acute pyelonephritis, pelvic inflammatory disease, curiuamniutis, bacterial vaginosis, preterm birth, non-gonococcal urethritis, miscarriage, infertility and spontaneous abortion), gardnerella vaginalis and streptococcus agalactiae...

Endometrial biopsies were obtained from 32 women with suspected pelvic inflammatory disease, of whom 23 (72%) had histopathological evidence of endometritis. Chlamydia trachomatis was isolated from the endometria of nine (39%) women (chlamydia group) but not from the other 14 (non-chlamydia group). Severe plasma cell endometritis and lymphoid follicles with transformed lymphocytes were signific...

The intracellular human bacterial pathogen Chlamydia trachomatis pursues effective strategies to protect infected cells against death-inducing stimuli. Here, we show that Chlamydia trachomatis infection evokes 3-phosphoinositide-dependent protein kinase-1 (PDPK1) signaling to ensure the completion of its developmental cycle, further leading to the phosphorylation and stabilization of MYC. Using...

Screening tests to detect Chlamydia trachomatis infections have advanced to permit the detection of nucleic acids from organisms. The development of these molecular assays that can detect and amplify the specific nucleic acids from the genes of C. trachomatis are called nucleic acid amplification tests (NAATs) and they have expanded the range of available specimen types to include noninvasive s...

References 1. Loeffelholz MJ, Lewinski CA, Silver SR, Purohit AP, Herman SA, Buonagurio DA, Dragon EA. Detection of Chlamydia trachomatis in endocervical specimens by polymerase chain reaction. J Clin Microbiol 1992;30:2847–51. 2. Bass CA, Jungkind DL, Silverman NS, Bondi JM. Clinical evaluation of a new polymerase chain reaction assay for detection of Chlamydia trachomatis in endocervical spec...

Chlamydia trachomatis is an obligate intracellular pathogen. Infection of susceptible individuals with this bacterium can trigger the development of reactive arthritis, an acute inflammation that is associated with the expression of the class I major histocompatibility antigen, HLA-B27. Other facultative intracellular pathogens, such as Yersinia and Salmonella spp., are also known triggers of r...