Previously, we have reported that enkephalins, cholecystokinin, and heavy metals show roughly parallel distributional patterns in the hippocampus. A substantial body of evidence indicates that cholecystokinin-octapeptide (CCK-8) and enkephalins act as neurotransmitters. A CCK-8 degrading enzyme was recently detected in brain synaptosomes. Its activity depended on free thiol groups and the prese...

The effects of cholecystokinin on feeding, and on plasma glucose and pancreatic hormone responses to a mixed-meal were determined in lean rhesus monkeys. Following an overnight fast the octapeptide of cholecystokinin (CCK-8) was administered intravenously over a 6 minute period coincident with the initiation of free feeding or an intragastric infusion of a mixed liquid diet. CCK-8 inhibited fee...

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

The cytochrome P-450-dependent drug metabolism system activities of rat colon microsomes are increased by gastroin testinal hormones. Pentagastrin, secretin, and cholecystokinin octapeptide increase the specific content of cytochrome P-450 over control and stimulate /V-demethylation, O-dealkylation, and polycyclic aromatic hydrocarbon hydroxylation to different degrees. Increase in hydroxylatio...

The cytochrome P-450-dependent drug metabolism system activities of rat colon microsomes are increased by gastroin testinal hormones. Pentagastrin, secretin, and cholecystokinin octapeptide increase the specific content of cytochrome P-450 over control and stimulate /V-demethylation, O-dealkylation, and polycyclic aromatic hydrocarbon hydroxylation to different degrees. Increase in hydroxylatio...