Case: A 51-year-old perimenopausal female presented with persistent vaginal bleeding, elevated human chorionic gonadotropin (hCG), and colonic and liver masses. Her initial diagnosis was felt to be metastatic colorectal cancer. Given that her hCG was rising, her pathology was re-reviewed and felt to be consistent with choriocarcinoma. To date, she received three cycles of EMA-CO chemotherapy wi...

Choriocarcinoma is a human chorionic gonadotrophin (HCG)-secreting tumor that comprises vascular channels. It has a tendency for widespread metastasis, common sites for which include the lung, vagina, brain, liver, bone, intestine, and kidney. We describe a 30-year-old female who presented with hepatitis-like features and bilateral diminution of vision, and subsequently developed hemothorax and...

Choriocarcinoma is a highly invasive and metastatic neoplasm which arises in women of reproductive age. It can be either gestational or nongestational in origin, but the latter form is very rare. Choriocarcinoma is characterized by the production of human chorionic gonadotropin. It can metastasize to distant organs such as lung, brain, liver, kidney, and vagina in the early stages of disease, b...

Gestational trophoblastic diseases (GTDs) are disorders with abnormal growth of the placenta. They are always associated with a conception.(1) Choriocarcinoma that is a malignant type of GTD, can spread virtually anywhere in the body through hematogenous or lymphatic route, but it most commonly spreads to lung, lower genital tract (cervix, vagina, and vulva), brain, and liver.(2) We report a ca...

A 67 year old man presented with haematuria, which on investigation was shown to be derived from a bladder tumour. The tumour initially was a typical transitional cell carcinoma except for rare trophoblastic cells. Over the next year and a half it gradually evolved into a choriocarcinoma. Postmortem examination confirmed that this was a primary choriocarcinoma of the bladder with no other sites...

BACKGROUND The pathogenesis of Gestational Trophoblastic Disease (GTD) is not clearly known. OBJECTIVE In this study, immunoexpression of proteins Bcl-2 and Beclin-1 in trophoblastic lesions and normal trophoblastic tissue was conducted to study the mechanism of apoptotic and autophagic cell death that is expected to complete the study of GTD pathogenesis. MATERIALS AND METHODS Bcl-2 and Be...

Surface epithelial stromal tumors account for approximately 60% of all ovarian tumors and approximately 90% of all ovarian malignancies. Sex cord stromal tumors account for 7% of all malignant ovarian tumors. Germ cell tumors make up only 3-7% of malignant ovarian tumors. A combination of serous carcinoma of the ovary and choriocarcinoma is rare. Until today such combination has been documented...