For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome. In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative "fragile breakage" model of chromosome evolution. In 2004, Sankoff and Trinh argued against the fragile breakage model and raised...

Key-words Disease name/synonyms Definition Differential diagnosis Etiology Clinical description Diagnostic methods Epidemiology Genetic counseling Antenatal diagnosis Management including treatment Unresolved questions References Abstract Bloom’s syndrome (BS) is a rare human autosomal recessive disorder belonging to a group of “chromosomal breakage syndromes”. BS is characterized by marked gen...

Understanding fluctuation-induced breakages in polymers has important implications for basic and applied sciences. Here I present for the first time an analytical treatment of the thermal breakage problem of a semi-flexible polymer model that is asymptotically exact in the low temperature and high friction limits. Specifically, I provide analytical expressions for the breakage propensity and ra...

(57) ABSTRACT A method for the identification of chromosomal inversions is described. Single-stranded sister chromatids are generated, for example by CO-FISH. A plurality of non-repetitive, labeled probes of relatively small size are hybridized to portions of only one of a pair of single-stranded sister chromatids. If no inversion exists, all of the probes will hybridize to a first chromatid. I...

a r t i c l e i n f o Keywords: Loose agglomerates Breakage Discrete element method Fine particles This paper presents a numerical study of the breakage of loose agglomerates based on the discrete element method. Agglomerates of fine mannitol particles were impacted with a target wall at different velocities and angles. It was observed that the agglomerates on impact experienced large plastic d...

NTIL comparatively recently there has been no compelling evidence U that genetic “interference” involves more than the occurrence of one crossover reducing the chance of another occurring in nearby regions. Genetic data from Drosophila have generally been interpreted as indicating that there is no “chromatid interference,” that is, that a crossover between two of the four chromatids does not in...

Chromosome segregation must be coordinated with cell cleavage to ensure correct transmission of the genome to daughter cells. Here we identify a novel mechanism by which Drosophila melanogaster neuronal stem cells coordinate sister chromatid segregation with cleavage furrow ingression. Cells adapted to a dramatic increase in chromatid arm length by transiently elongating during anaphase/telopha...

NE of the fundamental problems concerning the mechanism of cross0 ing over is the question of chromatid interference. In the absence of chromatid interference the identity of the chromatids involved in two or more chiasmata or points of crossing over is random. Positive chromatid interference would exist if a crossover between one pair of chromatids reduced their chances of being involved in a ...

A first principles model of a cement grinding circuit is developed for the purpose of multi-variable model predictive control (MPC). The model is based on a series of mixed flow reactors with an ideal screen to model flow between the two chambers in the ball mill. The separator is modelled by efficiency curves. Breakage of the particles is modelled as a first order process in terms of functions...

Cutting tools are widely used in manufacturing processes and drilling is the most commonly used machining process. Although drill-bits used in drilling may not be expensive, their breakage can cause damage to expensive work piece being drilled and at the same time has major impact on productivity. Predicting drill-bit breakage, therefore, is important in reducing cost and improving productivity...