A simple and accurate liquid chromatographic method was developed and validated for the analysis of bisoprolol fumarate in tablets. Chromatographic separation was achieved on a C18 column utilizing a mobile phase of buffer/acetonitrile (75:25, v/v, pH 5.6) at a flow rate of 1.0 mL/min. The separation was performed at room temperature. Detection was carried out at 226 nm, using a diode array det...

Analytical methodology for lorazepam in body fluids has been hampered by the extremely high sensitivity required for detection of the low plasma lorazepam concentrations achieved after usual therapeutic dose as well as by thermal instability of the 3-hydroxybenzodiazepine ring, making gas chromatographic methods difficult to standardize. High-performance liquid chromatographic (HPLC) methods ar...