Cyclophosphamide is one of most commonly used in malignant lymphomas. The antioxidants such as Vit C inhibits the toxicity of mutagens/carcinogens in animals and Humans. The protective effects of ascorbic acid (AA) on cyclophosmide (CP) induced cytogenetic damage was evaluated suing analysis of chromosomal aberrations in human lymphocytes in vitro. When cultures were treated with various doses ...

Male rats were treated of with a diet supplemented daily by the synthetic food colour erythrosine (0.08 and 0.4 g/kg diet) for 30 days. Changes in mutagenic activities, as an index for evaluating of possible toxic effects, were monitored by measuring chromosomal aberrations of rat bone marrow, nucleic acids and total protein concentrations of rat liver and brain. The present study found that er...

Chemoprotection by diet-derived antioxidants has emerged as a cost-effective approach in preventing genotoxicity and carcinogenicity. In this study, we investigated the protective effects of S-allylcysteine (SAC) and lycopene against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced genotoxicity. Quantification of bone marrow micronuclei and chromosomal aberrations in male Wistar rats was use...

Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, providing the first comprehensive catalogue of chromosomal aberrations in cancer GEM...

background: recurrent miscarriage is defined as two or more recurrent spontaneous miscarriages. several causes have been suggested, among which, chromosomal abnormalities in couples is considered to have a role in this regard. however, its significance varies among different populations. the present study was carried out to evaluate the prevalence of chromosomal aberrations in couples with recu...