Background and Objectives: studying chromosomal changes for anemia patients of children age (3month-12years ) in the city kut diagnosing those abnormalities resulting from having Methods: The chromosomes Patients to were analyzed studied using cytogenetic analysis detect aberrations caused by after collecting blood samples Al-Karama Teaching Hospital as well clinics Kut.Results: Chromosomal all...

OBJECTIVE This study was undertaken to provide epidemiologic data on the prevalence of holoprosencephaly and to assess the sensitivity of routine ultrasonographic screening in a low-risk population. STUDY DESIGN A population-based register of congenital abnormalities was used to identify reported cases of holoprosencephaly between 1985 and 1998. Sources included fetal losses, termination for ...

AIM To describe the epidemiology of congenital anomalies in Glasgow with special reference to secular trends. METHODS The prevalence of congenital anomalies was determined retrospectively in 233 777 births using the Glasgow Register of Congenital Anomalies for the period 1980-97. RESULTS The total prevalence of congenital anomalies was 324 per 10 000 births, declining by just over a third f...

MOTIVATION Microarray experiments can be used to help study the role of chromosomal translocation in cancer development through cancer outlier detection. The aim is to identify genes that are up- or down-regulated in a subset of cancer samples in comparison to normal samples. RESULTS We propose a likelihood-based approach which targets detecting the change of point in mean expression intensit...

background: genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. germ cells especially spermatozoa are more vulnerable to suffering from dna damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. methods: to investigate the effec...

OBJECTIVES To determine the excess risk of non-chromosomal congenital anomaly (NCA) among teenage mothers and older mothers. DESIGN AND SETTING Population-based prevalence study using data from EUROCAT congenital anomaly registers in 23 regions of Europe in 15 countries, covering a total of 1.75 million births from 2000 to 2004. PARTICIPANTS A total of 38,958 cases of NCA that were live bir...

OBJECTIVES Although there is concern that occupational exposures in some nursing professions may confer reproductive risks, there are few relevant studies. Our objective is to determine if a cohort of female registered nurses (RN) from British Columbia (BC), in comparison to BC women in general, have elevated rates of congenital anomalies, stillbirths, low birth weight, or prematurity in their ...

The most common cause of pregnancy losses is chromosomal anomalies. Fetal chromosomal anomalies are found in 90% preembryonic losses, 50% first trimester abortions, 2/3 malformed embryos, and 1/3 malformed fetuses. Considering all pregnancy losses, the rate 50%...

this report presents the cytogenetic findings (g -banded chromosomal analysis} in 383 cases referred for suspected chromosomal abnormalities because of abnormal clinical features. chromosomal aberrations were found in 63 116.5%) of these cases, free trisomy 21 (7%) being the most common abnormality , followed by 47, xxykaryotype (4%). the breakdown figures for each group is discussed in the text.