We reviewed the banded karyotypes of 24 human neuroblastomas and cell lines to identify any consistent chromosomal abnormalities. Six of the 10 primary tumors and one of the 14 cell lines were studied at this institution. Of the 24 neuroblastomas karyotyped, 20 were near-diploid, one was near-triploid, and 3 were near-tetraploid. One primary tumor had a diploid karyotype without numerical or st...

PURPOSE To investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS A total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also...

BACKGROUND Male infertility due to severe oligozoospermia and azoospermia has been associated with a number of genetic risk factors. METHODS In this study 150 men from couples requesting ICSI were investigated for genetic abnormalities, such as constitutive chromosome abnormalities, microdeletions of the Y chromosome (AZF region) and mutations in the cystic fibrosis transmembrane conductance ...

BACKGROUND AND OBJECTIVES Whole or partial trisomy 3 represents the most recurrent chromosomal abnormality occurring in marginal zone B-cell lymphoma (MZBCL), a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL). By conventional cytogenetic analysis, unbalanced translocations involving chromosome 3 and leading to a partial trisomy 3q were identified in a series of 14 MZBCL patients. Fluore...

AIM To test the hypothesis that, because the human papillomavirus (HPV) E2 protein represses viral early gene transcription, E2 gene sequence variation or disruption could play a part in the induction of the numerical chromosome abnormalities that have been described in squamous cervical lesions. METHODS The integrity and sequence of the E2 gene from 11 cervical intraepithelial neoplasia (CIN...

introduction: the types and incidence of the chromosomal abnormalities in failed fertilized oocytes that were taken after routine in vitro fertilization (ivf) and intracytoplasmic sperm injection (icsi) programs were investingated in patients referred the royan institute. materials and method: in this study, 364 air-dried preparation of failed fertilized oocytes after either ivf (91 samples) or...

Growth and development in humans begin at conception, which shows progress interdependence. Normal children show the characteristic of growth development. In with disorder, chromosomal abnormality may be found. This study aimed to determine patients disorder. The samples were taken from karyotype results Medical Genetics Laboratory, Faculty Medicine, Universitas Wijaya Kusuma Surabaya, 2010-202...

about 15% of couples have infertility problems, half of which are related to male factors. cytogenetic and genetic disorders account for about 10% of the male infertility problems. the aim of this study was to determine the frequency and types of both cytogenetic abnormalities and azf microdeletions of y chromosome in idiopathic azoospermic and oligospermic infertile men in west of iran. in thi...