Constrictive pericarditis — Constrictive pericarditis is the result of scarring and consequent loss of the normal elasticity of the pericardial sac. Pericardial constriction is typically chronic, but variants include subacute, transient, and occult constriction. Pathologically, this results in chronic inflammation and, frequently, calcification. Grossly, the pericardium is considerably thicker ...

Neuropathic pain due to peripheral nerve injury may be associated with abnormal central nerve activity. Glial cell-line-derived neurotrophic factor (GDNF) can help attenuate neuropathic pain in different animal models of nerve injury. However, whether GDNF can ameliorate neuropathic pain in the spinal cord dorsal horn (SCDH) in constriction-induced peripheral nerve injury remains unknown. We in...

Chronic pain is an undertreated epidemic affecting quality of life in at least 20% the global population, and CNS-related side effects, tolerance, addiction are common features current medications. ?-Conotoxin Vc1.1 potently elicits prolonged analgesia preclinical chronic constriction injury visceral hypersensitivity models neuropathic pain. A backbone-cyclized variant, cVc1.1, exhibits superio...

Management of painful peripheral neuropathies remains challenging, since patients with chronic pain respond poorly to the available pharmacopeia. In recent years, the G-protein-coupled receptor neurotensin (NT) type 2 (NTS2) emerged as an attractive target for treating transitory pain states. To date, however, there is no evidence for its role in the regulation of chronic peripheral neuropathie...