A study of dosage requirements undertaken among chronic OPD patients found on unnecessarily high drug dosage regimes. Basing on OPD experiences authors discuss long term treatment strategies and strongly advocate low dose intermittent oral therapy.

139 Editor’s note: Each month, this department features a discussion of an unusual diagnosis. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. As always, your comments are welcome via email at [email protected]. For diagnosis, see page 140 A17-year-old girl was admitted to our emergency department with complaints of sudden...

Pseudomonas aeruginosa is the predominant microorganism in chronic lung infection of cystic fibrosis patients. The chronic lung infection is preceded by intermittent colonization. When the chronic infection becomes established, it is well accepted that the isolated strains differ phenotypically from the intermittent strains. Dominating changes are the switch to mucoidity (alginate overproductio...

PURPOSE Primitive quiescent chronic myeloid leukemia (CML) cells are biologically resistant to imatinib mesylate, an inhibitor of the p210(BCR-ABL) kinase. The present study was designed to investigate whether either continuous or intermittent exposure of these cells to granulocyte-colony stimulating factor (G-CSF) in vitro can overcome this limitation to the effectiveness of imatinib mesylate ...

the purpose of this study was to determine the relationship between blood buffer capacity and aerobic power (vo2max) with ability to perform high intensity intermittent activities in young football players. methods: 27 male football players (age 17.66 ±0.49 years) selected as subjects. blood samples were collected before and after the yoyo intermittent test. then, after 48 hours, the bruce trea...

Objective-To assess the benefits and problems of chronic intermittent treatment with haemofiltration or haemodialysis or both in patients with severe chronic heart failure (New York Heart Association class III or IV) and oedema refractory to pharmacological treatment. Design and setting-A retrospective casecohort study. A general hospital in The Netherlands. Patients-The results of chronic inte...

introduction mild intermittent asthma is common in children and viral infections are responsible for the majority of exacerbations. as leukotrienes are potent inflammatory mediators, some studies have shown that montelukast, a leukotriene receptor antagonist, may be effective on reduction of asthma symptom. to determine whether a short course of montelukast in asthmatic children with common col...

Mitchell, Gordon S., Tracy L. Baker, Steven A. Nanda, David D. Fuller, Andrea G. Zabka, Brad A. Hodgeman, Ryan W. Bavis, Kenneth J. Mack, and E. B. Olson, Jr. Invited Review: Intermittent hypoxia and respiratory plasticity. J Appl Physiol 90: 2466–2475, 2001.— Intermittent hypoxia elicits long-term facilitation (LTF), a persistent augmentation (hours) of respiratory motor output. Considerable r...