نتایج جستجو برای: chronic lung allograft dysfunction
تعداد نتایج: 912965 فیلتر نتایج به سال:
Primary graft dysfunction grade correlates with acute kidney injury stage after lung transplantation
Background: Primary graft dysfunction (PGD) and acute kidney injury (AKI) are major early complications of lung transplantation associated with increased mortality. Lung after PGD can contribute to renal dysfunction; however, the association between AKI severity has not been thoroughly investigated. We analyzed grading staging, impact on subsequent changes chronic disease (CKD), including glome...
The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic lung allograft dysfunction, is poorly understood. Recent studies suggest that epigenetic regulation of microRNAs might play a role in its development. In this paper we present the application of a complex computational pipeline to perform enrichment analysis of miRNAs in pathways applied to the s...
Chronic lung allograft dysfunction (CLAD) remains the major barrier to long-term success after lung transplantation. This report compares gross and microscopic features of lungs removed from patients receiving a redo-transplant as treatment for CLAD. Lungs donated by patients with either the bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) phenotype of CLAD and ap...
PurposeLung transplantation (LT) relies heavily on calcineurin inhibitors for the prevention of rejection but they can lead to chronic kidney dysfunction. The use belatacept has been reported stabilize renal function in some cases and small series LT recipients (LTRs). We aimed describe our experience using as a pharmacological strategy preserve without allograft dysfunction larger cohort LTRs....
BACKGROUND Activins A and B, members of the TGF-β superfamily, are produced as part of the physiological response to tissue damage and the resulting proinflammatory response. Given that lung allograft reperfusion results in an inflammatory response, it is likely that the activins and their binding protein follistatin will form part of the regulatory response. There is a need to document the res...
OBJECTIVES Living-donor lobar lung transplantation (LDLLT) has been established as a life-saving procedure for critically ill patients who cannot wait for cadaveric lung transplantation. Chronic lung allograft dysfunction (CLAD) is the main cause of late morbidity and mortality in lung transplantation. Studies on CLAD in cadaveric lung transplantation have been extensively reported, but few rep...
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