Oesophageal candidiasis was diagnosed incidentally at endoscopy in two patients receiving omeprazole therapy. There were no other predisposing factors for the development of candidiasis. The infection was resolved rapidly by anti-candidal therapy and by stopping omeprazole. These findings suggest that gastric acid secretion and physiological reflux of acid into the oesophagus may play a protect...

We established a novel murine model of pharyngeal candidiasis maintaining stable yeast population and local symptoms characteristic of pharyngeal thrush. The persistent Candida-infection was prolonged by inhalation of beclomethasone dipropionate corticosteroid. The severity of infection lesions was evaluated by determining viable cell number of Candia albicans and scores representing symptomati...

OBJECTIVE To study the clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs. DESIGN Case-control study in cohorts of drug misusers and homosexual men. SETTING Outpatient clinic, Municipal Health Service, Amsterdam. SUBJECTS Misusers of intravenous drugs from our prospective cohort who seroconverted for HIV. Controls were drug users positive for HI...

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy is a rare recessive autoimmune disorder caused by a defect in a single gene called AIRE (autoimmune regulator). Characteristics of this disease include a variable combination of autoimmune endocrine tissue destruction, mucocutaneous candidiasis and ectodermal dystrophies. The development of Aire-knockout mice has provided an invalua...

We estimated the prevalence of oral lesions associated with human immunodeficiency virus (HIV-OLs) before and during the antiretroviral therapy (ART) era. The first period was 1997, when many patients received two types of antiretroviral (ARV) drugs. The second study period was 2004 through 2008, when all patients were treated with ART (a combination of two or three classes of drugs, including ...

hepatosplenic candidiasis is a fungal infection, which mostly affects patientswith hematologic malignancies such as leukemia. the pathogenesis of thisinfection is not clear yet, and the liver is the most commonly affected organ.diagnosis of hepatosplenic candidiasis can be only established via biopsy,since computed tomography (ct) scan, ultrasonography, and magneticresonance imaging (mri) yield...

Signal Transducer and Activator of Transcription 1 (STAT1) Gain Function (GoF) mutations can predispose to chronic mucocutaneous candidiasis (CMC). Long term therapy with oral azole antifungals result in resistance the need treat alternatives such as echinocandins. A pan-azole-resistant Candida albicans was isolated from a mouth swab 39-year-old woman lifelong CMC. Her condition warranted syste...