The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve t...

Although homeostasis is a commonly accepted concept, there incontrovertible evidence that biological processes and functions are variable variability occurs in cycles. In order to explain understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model emerged as first serious challenge homeostasis, going beyond its roots. Circadian rhythm predominant variat...

Biochemical, neural, endocrine and behavioral rhythms play a central role in many different aspects of the reproductive process in animals. These rhythms provide the basis for temporal organization of the reproductive functions of individual animals. In this paper, I introduce our results about the relationship of biological clock to reproductive function, analysis of mechanisms in biological c...

Osteoporosis is considered as one of the most common diseases that women face after their menopause and is caused by both genetic and environmental factors.  Dipeptidyl peptidase 4 (DPP-4) gene is one of the important genetic factors contributing in osteoporosis which has a direct and very important relationship with fasting. Fasting is one of the alternatives proved to reduce the DPP-4 level a...

Alterations of drug efficacy by the circadian clock are a concern when assessing drug therapies. Circadian rhythms persist in some cancer cells and are repressed in others. A better understanding of circadian activities generated within cancer cells could indicate therapeutic approaches that selectively disrupt rhythms and deprive cells of any benefits provided by circadian timing. Another opti...

Circadian rhythm dysfunction and cognitive decline, specifically memory loss, frequently accompany natural aging. Circadian rhythms and memory are intertwined, as circadian rhythms influence memory formation and recall in young and old rodents. Although, the precise relationship between circadian rhythms and memory is still largely unknown, it is hypothesized that circadian rhythm disruption, w...

Circadian rhythms are 24-h oscillations present in most eukaryotes and many prokaryotes that synchronize activity to the day-night cycle. They are an essential feature of organismal and cell physiology that coordinate many of the metabolic, biosynthetic, and signal transduction pathways studied in biology. The molecular mechanism of circadian rhythm is controlled both by signal transduction and...

Stimultaneous determination of the circadian rhythms of locomotor activity and body temperature was carried out in the rat. Deep body temperature was monitored continuously using a telemetric device. The circadian rhythm of locomotor activity was characterized by clustering of several bursts of activity during the dark period. The circadian rhythm of body temperature was also characterized by b...

As many other progressive fields of scientific inquiry, the study of circadian rhythms has experienced enormous growth in the recent past. From fungi and plants to birds and mammals, as well as from molecules and cells to organisms and populations, research on circadian rhythms has advanced at full speed into the 21st century. Circadian rhythm research is currently published in prestigious gene...

Clock circadian regulator (CLOCK)/brain and muscle arnt-like protein-1 (BMAL1) complex governs the regulation of circadian rhythm through triggering periodic alterations of gene expression. However, the underlying mechanism of circadian clock disruption in hepatocellular carcinoma (HCC) remains unclear. Here, we report that a long noncoding RNA (lncRNA), highly upregulated in liver cancer (HULC...