the influence of melatonin receptor 1a gene on litter size was studied in 150 ewes from zel (n=100) and naeini (n=50) sheep breeds. two restriction fragment length polymorphism (rflp) analyses were done to determine all genotypes occurring by variations at mnli and rsai restriction sites. the m and c were the most frequent alleles in both of these breeds. the mm genotype was predominant in zel ...

Recently, three distinct genotypes (1, 2 and 3) of human parvovirus B19 (B19) have been identified. However, the characteristics and distribution of B19 genotypes in Vietnam have not been investigated. Phylogenetic analysis using 49 subgenomic NS1/VP1u regions and two coding NS1-VP1/VP2 regions has been applied to investigate the prevalence of B19 genotypes in Vietnamese patients co-infected wi...

PURPOSE This study aimed to determine the expression and clinical significance of proteins that are involved in lipid metabolism in human breast tumors. METHODS Tumors from 476 breast cancer patients were used to construct tissue microarrays. Then, immunohistochemistry (IHC) for hormone-sensitive lipase (HSL), Perilipin 1 (PLIN1), fatty acid binding protein 4 (FABP4), carnitine palmitoyltrans...

The great majority of 121 hepatitis C virus (HCV) isolates obtained from 117 Italian patients with community-acquired infection could readily be typed by genotype-specific PCR. Subtype 1b was dominant (74 isolates); subtypes 2b, 2a, and 1a followed, with 19, 14, and 8 isolates, respectively. The six isolates that remained untyped by this method were classified as subtype 2c on the basis of sequ...

The purpose of this paper is to present some of the more carefully studied aspects of the preclinical toxicology of antineo-plastic agents, and apply these findings (with certain obvious cautions) to the area of environmental toxicology. Most of the studies to be described here are the result of applied toxicologic studies performed in support of the clinical introduction of new chemicals in th...

isoxazole (2a-l) and cyanopyridine (3a-l) derivatives have been prepared by condensing chalcones (1a-l) with hydroxylamine hydrochloride and malononitrile respectively. while compounds 1a-l have been synthesized by the reaction of p-(3’-chloro-2’-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. all the compounds were screened for their antitubercular and antimicrobial activities...