Hsp90 is a highly abundant chaperone whose clientele includes hundreds of cellular proteins, many of which are central players in key signal transduction pathways and the majority of which are protein kinases. In light of the variety of Hsp90 clientele, the mechanism of selectivity of the chaperone toward its client proteins is a major open question. Focusing on human kinases, we have demonstra...

This paper investigates the equilibrium implications of the presence of nonlinearly taxed, redundant securities, and of the resulting tax arbitrage opportunities. Heterogeneity in taxation leads to discrepancies in assets' pre-tax market prices of risk. We show that this mispricing is set so that agents e®ectively cooperate to minimize aggregate taxes, even though individually each agent may no...

Objective To explore the role of Australian nurses in the provision of inflammatory bowel disease (IBD) health services. Design A questionnaire survey. Setting Hospitals in Australia and the South West of the United Kingdom (UK). Subjects Inflammatory bowel disease nurses. Main outcome measure The diversity of IBD services. Results Twelve Australian and 19 UK nurses returned completed questionn...

This study focused on factors associated with the readiness of Kenyan health facilities to provide quality and appropriate care to family planning clientele; the degree to which health care providers foster informed selection of an appropriate contraceptive method; and the extent to which clients perceive services to be of high quality. Data was obtained from the 2004 Kenya Service Provision As...

This paper investigates whether beta can predict the expected return after controlling for the beta instability resulting from shift in the covariance structure. Such a shift is driven by idiosyncratic volatility’s clientele effect: speculative investors prefer stocks with high idiosyncratic volatility. Consequently, these stocks tend to have low future returns from overpricing, and high beta b...

For the longest time, we have hoped to have a bigger say in the political and administrative decisions that affect the quality of care we deliver our clientele and their families. Different strategies have been explored and certain avenues of reflection were put forth in an article printed in our news bulletin a year ago. Despite the level of our expertise, to date, seldom and only through grea...

This paper examines pairwise assortment similarities at U.S. supermarkets to understand how assortment composition and size are related to underlying factors that describe local store clientele, local competitive structure, and the retail outlets’ characteristics. The top-selling items, which cumulatively make up 50% of sales, are sold at nearly every store, but other items are viewed as option...

This paper investigates the equilibrium implications of the presence of nonlinearly taxed, redundant securities, and of the resulting tax arbitrage opportunities. Heterogeneity in taxation leads to discrepancies in assets' pre-tax market prices of risk. We show that this mispricing is set so that agents e®ectively cooperate to minimize aggregate taxes, even though individually each agent may no...

We propose a clientele-based model of the yield curve and optimal maturity structure of government debt. Clienteles are generations of agents at different lifecycle stages in an overlappinggenerations economy. An optimal maturity structure exists in the absence of distortionary taxes and induces efficient intergenerational risksharing. If agents are more risk-averse than log, then an increase i...

Background. In 1989 the South Carolina Department of Mental Health (SCDMH) established the Deaf Services program to supplement the care provided to its deaf clientele by local mental health center psychiatrists with a staff of case managers and other personnel specially trained in serving the needs of this population. Although each client's Deaf Services case manager is fluent in American Sign ...