Correspondence to: Dr Kay Brune, Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University ErlangenNuremberg, Fahrstrasse 17, 91052 Erlangen, Germany; [email protected] Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic ...

The proposed rule for the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88) describes uniform standards for the design of proficiency testing (PT) challenges and for the evaluation of laboratory performance. Successful performance on PT is a condition for laboratory certification by the federal Department of Health and Human Services. We conducted a retrospective evaluation of PT da...

Historically, early identification and characterization of adverse effects of industrial chemicals was difficult because conventional toxicological test methods did not meet R&D needs for rapid, relatively inexpensive methods amenable to small amounts of test material. The pharmaceutical industry now front-loads toxicity testing, using in silico, in vitro, and less demanding animal tests at ear...

Katarina Vučićević1, Branislava Miljković1, Sandra Vezmar Kovačević1, Zoran Todorović2, Milica Prostran2 and Iztok Grabnar3 1Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, 2Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, 3Chair of Biopharmaceutics and Pharmacokinetics, Faculty of Ph...

Background: Chemical exposure is a major health problem globally. Poison control centers (PCCs) play a leading role both in developed and developing countries in the prevention and control of poisonous chemical exposures. In this study, we aimed to assess the current state of PCCs in Pakistan and highlight capacity building needs in these centers. Methods: A cross-sectional survey of the two re...

Purpose In recent years, several publications have demonstrated the interest and usefulness of pharmacogenetics in forensic toxicology. However, this approach remains namely focused on DNA-based phenotype, which may potentially lead to misinterpretation. Other determinants such as co-medication or physiological parameters also impact phenotype. This article aims highlight importance considering...

Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Fahrstr. 17, 91054 Erlangen, Germany (J.K., H.G., K.M., M.F.F.) Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, 17487 Greifswald, Germany (M.K.) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttg...