A 44-year-old woman presented at our department in 2003 with multiple pruritic papules spread over her trunk and extremities, and was diagnosed with LP. No mucosal lesions were observed. The diagnosis was histologically confirmed. Viral infection, contact with triggering substances, and use of medications were all ruled out. Treatment with sulfasalazine was begun and 5 months later, the lesions...

BACKGROUND AND AIM Ingenol mebutate (IngMeb) is an effective treatment for actinic keratosis. In this study, we hypothesized that repeated treatments with IngMeb may prevent progression of UV-induced photodamage, and that concurrent application of a corticosteroid may reduce IngMeb-induced local skin responses (LSR). METHODS Hairless mice (n = 60; 3 groups of 20 mice) were irradiated with sol...

Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis often misdiagnosed. It is uncommon in infants and children accounting for 4% of cases. A one-year-old male in paediatric ICU ventilated for bronchopneumonia was referred with ulcerated areas on his neck and axilla corresponding to sites of recent removal of central and arterial lines. Examination revealed areas of deep ulc...

BACKGROUND Lichen sclerosus is an inflammatory disease of unknown etiology affecting the anogenital skin and associated with the development of squamous cell carcinoma. It is not known whether long-term topical treatment with a potent steroid can cure this disease and thus prevent malignant evolution. OBJECTIVES To analyze the rates of remission, recurrence, and chronic evolution of vulvar li...

Topical steroids have been widely used in the treatment of symptomatic oral lesions to reduce pain and inflammation. Potent topical steroids such as clobetasol propionate, fluocinolone acetonide (FA), and fluocinonide have been widely used in the treatment of severe oral mucosal lesions. Many reports have demonstrated that these steroids were effective in treating oral lesions with only minor s...

Bullous morphea is a rare form of morphea characterized with bullae on or around atrophic morphea plaques. Whereas lichen sclerosus et atrophicus (LSA) is a disease the etiology of which is not fully known, and which is characterized with sclerosis. Coexistence of morphea and LSA has been identified in some cases. Some authors believe that these two diseases are different manifestations which a...

Cip-interacting zinc finger protein 1 (Ciz1) stimulates DNA replication and has been implicated in the tumorigenesis of breast cancer cells. In order to investigate the possibility of using medicinal glucocorticoids against breast cancer, we studied whether certain glucocorticoids affect the expression of Ciz1. The in vitro effect of clobetasol tr...

Oral lichen planus (OLP) is an immune-mediated disease of the oral mucosa with idiopathic aetiology. It frequently treated topical corticosteroids (applied as gels, mouthwashes, or sprays); however, mucosal exposure times are short because removal by constant flow saliva and mechanical forces. In this study we used cell monolayers, well equivalents (OMEs) containing activated T-cells, to examin...

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can produce marked neurological deficit. Current NMO therapies include immunosuppressants, plasma exchange and B-cell depletion. Here, we evaluated 14 potential remyelinating drugs emerging from prior small molecule screens done to identify drugs for repurposing in multiple sclerosis and other...