Background and Objectives: Epidural anesthesia is a popular technique for providing lower limb surgeries. Dexmedetomidine Clonidine are known to enhance the effect of local anaesthetics. The purpose this study was compare impact dexmedetomidine clonidine on onset duration epidural anaesthesia using bupivacaine. Methods: After IEC approval, prospective, randomized, double blinded conducted 60 AS...

The effect of intravenous clonidine on pentagastrin-induced gastric acid secretion has been studied in conscious dogs with Heidenhain pouches. Dose-dependent enhancement of secretion was found in response to clonidine (5-20 mu/kg). Clonidine (20 mug/kg) increased the maximal secretory rate to pentagastrin to a value not significantly different from the maximal response to histamine.

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immed...

In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during...

In this study, three lines of evidence suggest a role for α(2)-adrenoreceptors in rat pup odor-preference learning: olfactory bulb infusions of the α(2)-antagonist, yohimbine, prevents learning; the α(2)-agonist, clonidine, paired with odor, induces learning; and subthreshold clonidine paired with subthreshold β-adrenoceptor activation also recruits learning. Increased mitral cell layer pCREB o...

BACKGROUND Clonidine was originally used to lower blood pressure. It acts on the central nervous system and may reduce withdrawal symptoms in various addictive behaviours, including tobacco use. OBJECTIVES The aim of this review is to determine clonidine's effectiveness in helping smokers to quit. SEARCH STRATEGY We searched the Cochrane Tobacco Addiction Group trials register for trials of...

We tested the hypothesis that clonidine produces a dose-dependent increase in the sweating threshold but does not reduce the gain of sweating. Six healthy male volunteers were evaluated, each on three separate days in random order. In one, saline was administered; in another, a 2-micrograms/kg bolus of clonidine was followed by an infusion at 2 micrograms.kg-1.h-1, and on a third day, a 4-micro...

BACKGROUND Clonidine, a partial presynaptic and postsynaptic alpha-adrenoceptor agonist, has been shown to lower blood pressure in normal subjects but not in tetraplegics; however, the mechanisms of this action have not been elucidated. METHODS AND RESULTS The hemodynamic and hormonal basis of the hypotensive action of clonidine was investigated in tetraplegics with complete cervical spinal c...

In a previous study, we showed that clonidine, an α₂-adrenoceptor agonist, administered prior to hypoxia improves post-hypoxic contractility (PC) and endothelium-dependent dilatation (PED) in isolated young rat aortas. These effects were not investigated in old rats. Ageing influences vascular physiology and modifies the response to vasoactive drugs. Some drugs, such as simvastatin, improve end...